International Journal of Hematology

, Volume 79, Issue 1, pp 31–36 | Cite as

Acute Promyelocytic Leukemia during Pregnancy: Report of 3 Cases

  • Ugo Consoli
  • Amalia Figuera
  • Giuseppe Milone
  • Carmela Rita Meli
  • Giulia Guido
  • Francesco Indelicato
  • Gaetano Moschetti
  • Salvatore Leotta
  • Antonella Tornello
  • Massimo Poidomani
  • Pamela Murgano
  • Valeria Pinto
  • Rosario Giustolisi
Case Report


Acute promyelocytic leukemia (APL) is characterized by onset at a young age and a life-threatening hemorrhagic diathesis, which is attributed to a disseminated intravascular coagulation (DIC)-like coagulopathy. The discovery of all-trans-retinoic acid has changed the course of APL treatment by reducing the onset of DIC and inducing a complete and durable remission in more than 90% of patients. The occurrence of APL during pregnancy is not a frequent event, but the management of these patients raises many therapeutic and ethical dilemmas and requires a careful clinical case evaluation of fetal and maternal risk, coagulation status, the parents’ wishes, and therapeutic options. Here we describe 3 patients with APL diagnosed during pregnancy. Clinical data and the therapeutic approaches are presented. In the discussion, we analyze clinical decisions and therapeutic options and compare our cases with those found in the literature. Int J Hematol. 2004;79:31-36.

Key words

APL ATRA Pregnancy 


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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Ugo Consoli
    • 1
  • Amalia Figuera
    • 1
  • Giuseppe Milone
    • 1
  • Carmela Rita Meli
    • 1
  • Giulia Guido
    • 1
  • Francesco Indelicato
    • 1
  • Gaetano Moschetti
    • 1
  • Salvatore Leotta
    • 1
  • Antonella Tornello
    • 1
  • Massimo Poidomani
    • 1
  • Pamela Murgano
    • 1
  • Valeria Pinto
    • 1
  • Rosario Giustolisi
    • 1
  1. 1.Chair and Division of Haematology with Bone Marrow Transplantation UnitUniversity of CataniaCataniaItaly

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