Summary
A skeletal abnormality, termed pigtail, in the house mouse is described which phenotypically resembles flexed tail. In a certain small proportion of litters, one or more young with spina bifida aperta occurred, especially in the more highly inbred litters. Genetically, pigtail is a recessive character, caused either by two complementary factors, or—more probably—by one main gene interacting with a number of modifiers which affect the penetration. Penetration is never 100%. In genetically pigtail litters, it varies round about 20%. It is not noticeably dependent on age of mother, degree of expression in the parents, degree of inbreeding or selection; but there exists a significant, though slight, negative correlation between litter-size and percentage of manifestation in homozygous litters, suggesting some intra-uterine, non-genetical influence on the development of the abnormality.
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References
Beck, O. (1922). “Spina bifida occulta und ihre ätiologische Beziehung zu Deformitäten der unteren Extremitäten.”Ergebn. Chir. Orthop. 15, 491–568.
Hunt, H. R., Mixter, R. &Permar, D. (1933). “Flexed tail in the mouse,Mus musculus.”Genetics,18, 334–66.
Mixter, R. &Hunt, H. R. (1933). “Anaemia in the flexed tailed mouse,Mus musculus.”Genetics,18, 366–87.
Timoféeff-Ressovsky, N. W. (1934). “Über den Einfluss des genotypischen Milieus und der Aussenbedingungen auf die Realisation des Genotyps.”Nachr. Ges. Wiss. Göttingen, Math.-Phys. Kl., Biologie, Neue Folge,1, 53–106.
Wright, S. (1922). “Coefficients of inbreeding and relationship.”Amer. Nat. 56, 330–8.
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Crew, F.A.E., Auerbach, C. “Pigtail,” a hereditary tail abnormality in the house mouse,Mus musculus . Journ. of Genetics 41, 267–274 (1941). https://doi.org/10.1007/BF02983023
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DOI: https://doi.org/10.1007/BF02983023