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International Journal of Hematology

, Volume 76, Issue 5, pp 420–426 | Cite as

The Control of Expression of the α-Globin Gene Cluster

  • Hua-bing Zhang 
  • De-Pei Liu 
  • Chih-Chuan Liang 
Progress in hematology

Abstract

The α-globin gene cluster is located at the very tip of the short arm of chromosome 16. It produces the α-like globins, which is combined with the β-like globins to form hemoglobin, and its mutants cause α-thalassemia, which is one of the most common genetic diseases. Its expression shows a tissue and developmental stage specificity that is balanced with that of the β-globin gene cluster. In this article, we summarize the research on the control of expression of the α-globin gene cluster, mainly with respect to the α—major regulatory element (α-MRE): HS-40, the tissue-specific and developmental control of its expression, and its chromosomal environment. In summary, the α-globin gene cluster is expressed in an open chromosomal environment; HS-40, the 5-flanking sequence, the transcribed region, and the 3-flanking sequence interact to fully regulate its expression.Int J Hematol. 2002;76:420-426.

Key words

α-Globin gene cluster Control of expression HS-40 Developmental control Chromosomal environment 

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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Hua-bing Zhang 
    • 1
  • De-Pei Liu 
    • 1
  • Chih-Chuan Liang 
    • 1
  1. 1.National Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing, P. R.China

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