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Successful Treatment of Progressive NK cell Lymphoma with Allogeneic Peripheral Stem Cell Transplantation Followed by Early Cyclosporine Tapering and Donor Leukocyte Infusions

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Abstract

We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-dose chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment, the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report, the patient has been well for more than 2 years.

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Authors and Affiliations

  1. Department of Biopathology Science, Graduate School of Medicine and Dentistry, Okayama University Graduate Schools, Japan

    Masanori Makita, Yoshinobu Maeda, Katsuto Takenaka, Katsuji Shinagawa, Kazutaka Sunami, Yasushi Hiramatsu, Nobuharu Fujii, Fumihiko Ishimaru, Kazuma Ikeda, Kenji Niiya & Mine Harada

  2. Department of Pathology, Graduate School of Medicine and Dentistry, Okayama University Graduate Schools, Okayama, Japan

    Tadashi Yoshino

  3. First Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Shigenobu, Ehime, Japan

    Masanori Makita

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  1. Masanori Makita
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  2. Yoshinobu Maeda
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  3. Katsuto Takenaka
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  4. Katsuji Shinagawa
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  5. Kazutaka Sunami
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  6. Yasushi Hiramatsu
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  7. Nobuharu Fujii
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  8. Fumihiko Ishimaru
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  9. Kazuma Ikeda
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  10. Kenji Niiya
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  11. Tadashi Yoshino
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  12. Mine Harada
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Correspondence to Masanori Makita.

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Makita, M., Maeda, Y., Takenaka, K. et al. Successful Treatment of Progressive NK cell Lymphoma with Allogeneic Peripheral Stem Cell Transplantation Followed by Early Cyclosporine Tapering and Donor Leukocyte Infusions. Int J Hematol 76, 94–97 (2002). https://doi.org/10.1007/BF02982726

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  • DOI: https://doi.org/10.1007/BF02982726

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