Abstract
We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelosuppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270.This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Utsunomiya A, Miyazaki Y, Takatsuka Y, et al. Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation.Bone Marrow Transplant. 2001;27:15–20.
Borg A, Liu Yin JA, Johnson PRE, Tosswill J, Saunders M, Morris D. Successful treatment of HTLV-1-associated acute adult T-cell leukaemia lymphoma by allogeneic bone marrow transplantation.Br J Haematol. 1996;94:713–715.
Obama K, Tara M, Sao H, et al. Allogeneic bone marrow transplantation as a treatment for adult T-cell leukemia.Int J Hematol. 1999;69:203–205.
Sobue R, Yamauchim T, Miyamura K, et al. Treatment of adult T cell leukemia with mega-dose cyclophosphamide and total body irradiation followed by allogeneic bone marrow transplantation.Bone Marrow Transplant. 1987;2:441–444.
McSweeney PA, Niederwieser D, Shizuru JA, et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects.Blood. 2001;97:3390–3400.
Thiede C, Florek M, Bornhäuser M, et al. Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detection.Bone Marrow Transplant. 1999;23:1055–1060.
Jacobson S, Shida H, McFarlin DE, Fauci AS, Koenig S. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease.Nature. 1990;348: 245–248.
Kannagi M, Matsushita S, Shida H, Harada S. Cytotoxic T cell response and expression of the target antigen in HTLV-I infection.Leukemia. 1994;8:S54-S59.
Ohashi T, Hanabuchi S, Kato H, et al. Prevention of adult T-cell leukemia-like lymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T-cell leukemia virus type 1 Tax-coding DNA vaccine.J Virol. 2000;74: 9610–9616.
Lofters W, Campbell M, Gibbs N, Cheson BD. 2-Deoxycoformycin therapy in adult T-cell leukemia/lymphoma.Cancer. 1987;60: 2605–2608.
Steis RG, Urba WJ, Kopp WC, Alvord WG, Smith II JW, Longo DL. Kinetics of recovery of CD4+ T cells in peripheral blood of deoxycoformycin -treated patients.J Natl Cancer Inst. 1991;83:1678–1679.
Kamihira S, Dateki N, Sugahara K, et al. Real-time polymerase chain reaction for quantification of HTLV-1 proviral load: application for analyzing aberrant integration of the proviral DNA in adult T-cell leukemia.Int J Hematol. 2000;72:79–84.
Khouri IF, Saliba RM, Giralt SA, et al. Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus- host disease, and treatment-related mortality.Blood. 2001;98: 3595–3599.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Abe, Y., Yashiki, S., Choi, I. et al. Eradication of Virus-Infected T-Cells in a Case of Adult T-Cell Leukemia/Lymphoma by Nonmyeloablative Peripheral Blood Stem Cell Transplantation with Conditioning Consisting of Low-Dose Total Body Irradiation and Pentostatin. Int J Hematol 76, 91–93 (2002). https://doi.org/10.1007/BF02982725
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02982725