International Journal of Hematology

, Volume 76, Issue 1, pp 69–73 | Cite as

Lineage Conversion From Acute Lymphoblastic Leukemia to Acute Myeloid Leukemia on Rearrangement of the IgH Gene in a Patient with Down Syndrome

  • Kazuya Tsuboi
  • Makoto Yazaki
  • Hiroshi Miwa
  • Shinsuke Iida
  • Shogo Banno
  • Atsushi Wakita
  • Masakazu Nitta
  • Ryuzo Ueda
Review Article


A patient with Down syndrome (DS) at the time of diagnosis of acute lymphoblastic leukemia (ALL) had a relapse with acute myeloid leukemia (AML) after 4 years of complete remission. Although the diagnosis was AML, the leukemic blasts at relapse showed an immunoglobulin H rearrangement that turned out to be identical to that of the initial ALL blasts. It is thought that the leukemic precursor cells of this patient had the potential to differentiate into both lymphoid and myeloid lineages. This case is important for investigating target cells for leukemogenesis in DS.

Key words

Down syndrome AML ALL IgH CDRIII 


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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Kazuya Tsuboi
    • 1
    • 2
  • Makoto Yazaki
    • 3
  • Hiroshi Miwa
    • 2
  • Shinsuke Iida
    • 1
  • Shogo Banno
    • 1
  • Atsushi Wakita
    • 1
  • Masakazu Nitta
    • 2
  • Ryuzo Ueda
    • 1
  1. 1.Second Department of Internal MedicineNagoya City University Medical SchoolJapan
  2. 2.Department of Internal Medicine, Division of HematologyAichi Medical UniversityAichiJapan
  3. 3.Department of PediatricsNagoya City University Medical SchoolNagoyaJapan

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