International Journal of Hematology

, Volume 76, Issue 1, pp 55–60 | Cite as

Histologic Verification of Leukemia, Myelodysplasia, and Multiple Myeloma Diagnoses in Patients in Ukraine, 1987–1998

  • Irina Dyagil
  • Mircea Adam
  • Gilbert W. Beebe
  • J. David Burch
  • Svetlana N. Gaidukova
  • Daniel Gluzman
  • Natalia Gudzenko
  • Victor Klimenko
  • LoAnn Peterson
  • Robert F. Reiss
  • Stuart C. Finch
Review Article


In preparation for a possible large epidemiological study of radiation-related leukemia in Chernobyl clean-up workers of Ukraine, histologic evaluation of 62 cases of leukemia and related disorders was conducted by a panel of expert hematologists and hematopathologists from the United States, France, and Ukraine. All cases were randomly selected from a surrogate population of men in the general population of 6 regions of Ukraine who were between the ages of 20 and 60 years in 1986 and were reported to have developed leukemia, myelodysplasia, or multiple myeloma between the years 1987 and 1998. The hematologists and hematopathologists on the panel were in agreement with one another and with the previously reported diagnoses and classifications of about 90% of the cases of acute and chronic leukemia in the study. These results suggest that strong reliance can be placed on the clinical diagnoses of acute and chronic forms of leukemia and multiple myeloma that have occurred in Ukrainian Chernobyl clean-up workers providing that the diagnoses are supported by records of the patients having had adequate histologic bone marrow studies. The number of cases in this study with the diagnosis of myelodysplasia, however, was too small to draw firm conclusions.

Key words

Ukraine Leukemia Multiple myeloma Myelodysplasia 


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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Irina Dyagil
    • 1
  • Mircea Adam
    • 2
  • Gilbert W. Beebe
    • 3
  • J. David Burch
    • 4
  • Svetlana N. Gaidukova
    • 5
  • Daniel Gluzman
    • 6
  • Natalia Gudzenko
    • 1
  • Victor Klimenko
    • 1
  • LoAnn Peterson
    • 7
  • Robert F. Reiss
    • 4
  • Stuart C. Finch
    • 8
  1. 1.Research Center for Radiation MedicineKievUkraine
  2. 2.Hospital d’enfants Armand TrousseauParisFrance
  3. 3.National Cancer InstituteNational Institutes of HealthBethesdaUSA
  4. 4.College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  5. 5.Kiev Medical Academy for Postgraduate Medical EducationKievUkraine
  6. 6.R. E. Kavetsky Institute of Experimental PathologyKievUkraine
  7. 7.Northwestern University Medical SchoolChicagoUSA
  8. 8.Robert Wood Johnson Medical SchoolUniversity of Medicine and Dentistry of New Jersey, The Cooper Health SystemCamdenUSA

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