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Sarcopenia: Diagnosis and treatment

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References

  1. 1.

    Critchley M. The neurology of old age. Nutrition. 2001;17:660–663.

    Article  Google Scholar 

  2. 2.

    Rosenberg IH. Sarcopenia: Origins and clinical relevance. J Nutr. 1997;127(Suppl 5):S990-S991.

    Google Scholar 

  3. 3.

    Morley JE. Anorexia, sarcopenia, and aging. Nutrition. 2001 ;17:660–663.

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Rolland YM, Perry HM 3rd, Patrick P, et al. Loss of appendicular muscle mass and loss of muscle strength in young postmenopausal women. J Gerontol A Biol Sci Med Sci. 2007;62:330–335.

    PubMed  Google Scholar 

  5. 5.

    Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998;147:755–763.

    PubMed  CAS  Google Scholar 

  6. 6.

    Morley JE, Baumgartner RN, Roubenoff R, et al. Sarcopenia. J Lab Clin Med. 2001;137:231–243.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002;50:889–896.

    PubMed  Article  Google Scholar 

  8. 8.

    Tanko LB, Movsesyan L, Mouritzen U, Christiansen C, Svendsen OL. Appendicular lean tissue mass and the prevalence of sarcopenia among healthy women. Metabolism. 2002;51:69–74.

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Melton LJ, Khosla S, Crowson CS, O’Connor MD, O’Fallon WM, Riggs BL. Epidemiology of sarcopenia. J Am Geriatr Soc. 2000;48:625–630.

    PubMed  Google Scholar 

  10. 10.

    Gillette-Guyonnet S, Hourhashemi F, et al. Body composition in French women 75+ years of age: the EPIDOS study. Mech Ageing Dev. 2003;124:311–316.

    PubMed  Article  Google Scholar 

  11. 11.

    Castillo EM, Goodman-Gruen D, Kritz-Silverstein D, et al. Sarcopenia in elderly men and women: The Rancho Bernardo Study. Am J Prev Med. 2003;25:226–231.

    PubMed  Article  Google Scholar 

  12. 12.

    Ianuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci. 2002;57:M2771-M777.

    Google Scholar 

  13. 13.

    Morley JE, Kim MJ, Haren MT, Kevorkian R, Banks WA. Frailty and the aging male. Aging Male. 2005;8:135–140.

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc. 2004;52:80–85.

    PubMed  Article  Google Scholar 

  15. 15.

    Baumgartner RN, Wayne SJ, Waters DL et al. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res. 2004;12:1995–2004.

    PubMed  Article  Google Scholar 

  16. 16.

    Goodpaster BH, Carlson CL, Visser M, et al. Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. J Appl Physiol. 2001;90:2157–2163.

    PubMed  CAS  Google Scholar 

  17. 17.

    Larsson L. Histochemical characteristics of human skeletal muscle during aging. Acta Physiol Scand. 1983;117:469–471.

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Reeves ND, Narici MB, Maganaris CN. Myotendinous plasticity to ageing and resistance exercise in humans. Exp Physiol. 2006;91:483–498.

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Narici MV, Maganaris CN. Adaptability of elderly human muscles and tendons to increased loading. J Anat 2006;208:433–443.

    PubMed  Article  Google Scholar 

  20. 20.

    Thomas DR, Ashmen W, Morley JE, Evans WJ. Nutritional management in long-term care: development of a clinical guideline. Council for Nutritional Strategies in Long-Term Care. J Gerontol A BIol Sci Med Sci. 2000;55:M725-M734.

    PubMed  CAS  Google Scholar 

  21. 21.

    Morley JE. Weight loss in the nursing home. J Am Med Dir Assoc. 2007;8:201–204.

    PubMed  Article  Google Scholar 

  22. 22.

    Morley JE. Weight loss in older persons: new therapeutic approaches. Curr Pharm Des.2007;13:3637–3647.

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Morley JE. Anorexia and weight loss in older persons. J Gerontol A Biol Sci Med Sci.2003;58:131–137.

    PubMed  Google Scholar 

  24. 24.

    Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr. 2006;83:735–743.

    PubMed  CAS  Google Scholar 

  25. 25.

    Thomas DR, Cote TR, Lawhorne L, et al. Understanding clinical dehydration and its treatment J Am Med Dir Assoc. 2008;9: june issue (In Press)

  26. 26.

    Kalantar-Zadeh K, Horwich TB, Oreopoulos A, et al. Risk factor paradox in wasting diseases. Curr Opin Clin Nutr Metab Care. 2007;10:433–442.

    PubMed  Article  Google Scholar 

  27. 27.

    Manini TM, Everhart JE, Patel KV, et al. Daily activity energy expenditure and mortality among older adults. JAMA. 2006;296:171–179.

    PubMed  Article  CAS  Google Scholar 

  28. 28.

    Hughes VA, Roubenoff R, Wood M, et al. Anthropometric assessment of 10-y changes in body composition in the elderly. Am J Clin Nutr. 2004;80:475–482.

    PubMed  CAS  Google Scholar 

  29. 29.

    Kortebien P, Ferrando A, Lombeida J, et al. Effect of 1 days of bed rest on skeletal muscle in healthy older adults. JAMA. 2007;297:1772–1774.

    Article  Google Scholar 

  30. 30.

    Roubenoff R. Physical activity, inflammation, and muscle loss. Nutr Rev. 2007;65(12 Pt 2):S208-S212.

    PubMed  Article  Google Scholar 

  31. 31.

    Frankel JE, Bean JF, Frontera WR. Exercise in the elderly: research and clinical practice. Clin Geriatr Med. 2006;22:239–256.

    PubMed  Article  Google Scholar 

  32. 32.

    Singh MA. Exercise to prevent and treat functional disability. Clin Geriatr Med. 2002;18:431–462.

    PubMed  Article  Google Scholar 

  33. 33.

    Heath JM, Stuart MR. Prescribing exercise for frail elders. J Am Board Fam Pract 2002;15:218–228.

    PubMed  Google Scholar 

  34. 34.

    van Kan GA, Rolland YM, Morley JE, Vellas B. Frailty: toward a clinical definition. J Am Med Dir Assoc. 2008;9:71–72.

    Article  Google Scholar 

  35. 35.

    Kotz CM, Wang C, Teske JA, et al. Orexin A mediation of time spent moving in rats: neural mechanisms. Neuroscience. 2006;142:29–36.

    PubMed  Article  CAS  Google Scholar 

  36. 36.

    Simonsick EM, Guralnik JM, Volpato S, et al. Just get out the door! Importance of walking outside the home for maintaining mobility; findings from the women’s health and aging study. J Am Geriatr Soc. 2005;53:198–203.

    PubMed  Article  Google Scholar 

  37. 37.

    Bartali B, Frongillo EA, Bandinelli S, et al. Low nutrient intake is an essential component of frailty in older persons. J Gerontol A Biol Sci Med Sci. 2006;61:589–593.

    PubMed  Google Scholar 

  38. 38.

    Chapman IM, Macintosh CG, Morley JE, Horowitz M. The anorexia of ageing. Biogerontology. 2002;3:67–71.

    PubMed  Article  CAS  Google Scholar 

  39. 39.

    Hays NP, Roberts SB. The anorexia of aging in humans. Physiol Behav. 2006;88:257–266.

    PubMed  Article  CAS  Google Scholar 

  40. 40.

    Morley JE. Decreased food intake with aging. J Gerontol A Biol Sci Med Sci. 2001;56(Spec 2):81–88.

    PubMed  Google Scholar 

  41. 41.

    Morley JE. Weight loss in the nursing home. J Am Med Dir Assoc. 2007;8:201–204.

    PubMed  Article  Google Scholar 

  42. 42.

    Morley JE. Kraenzle D. Causes of weight loss in a community nursing home. J Am Geriatr Soc. 1994;42:583–585.

    PubMed  CAS  Google Scholar 

  43. 43.

    Cabrera MA, Mesas AE, Garcia AR, de Andrade SM. Malnutrition and depression among community-dwelling elderly people. J Am Med Dir Assoc. 2007;8:582–584.

    PubMed  Article  Google Scholar 

  44. 44.

    Volpi E, Sheffield-Moore M, Rasmussen BB, Wolfe RR. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA. 2001;286:1206–1212.

    PubMed  Article  CAS  Google Scholar 

  45. 45.

    Paddon-Jones D, Sheffield-Moore M, Urban RJ, et al. Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab. 2004;89:4351–4358.

    PubMed  Article  CAS  Google Scholar 

  46. 46.

    Candow DG, Chilibeck PD. Effect of creatine supplementation during resistance training on muscle accretion in the elderly. J Nutr Health Aging. 2007;11:185–188.

    PubMed  CAS  Google Scholar 

  47. 47.

    Olsen S, Aagaard P, Kadi F, et al. Creatine supplementation augments the increase in satellite cell and myonuclei number in human muscle induced by strength training. J Physiol. 2006;573(Pt 2):525–534.

    PubMed  Article  CAS  Google Scholar 

  48. 48.

    Morley JE, Kaiser FE, Perry HM 3rd, et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism. 1997;46:410–413.

    PubMed  Article  CAS  Google Scholar 

  49. 49.

    Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrionl Metab. 2002;87:589–598.

    Article  CAS  Google Scholar 

  50. 50.

    Morley JE, Perry HM 3rd. Androgens and women at the menopause and beyond. J Gerontol A BIol Sci Med Sci. 2003;58:M409-M416.

    PubMed  Google Scholar 

  51. 51.

    Morley JE. The diagnosis of late life hypogonadism. Aging Male. 2007;10:217–220.

    PubMed  Article  Google Scholar 

  52. 52.

    Wittert GA, Chapman IM, Haren MT, et al. Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. J Gerontol A Biol Sci Med Sci. 2003;58:618–625.

    PubMed  Google Scholar 

  53. 53.

    Snyder PJ, Peachey H, Hannoush P, et al. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab. 1999;84:2647–2653.

    PubMed  Article  CAS  Google Scholar 

  54. 54.

    Morley JE, Perry HM 3rd, Kaiser FE, et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc. 1993;41:149–152.

    PubMed  CAS  Google Scholar 

  55. 55.

    Ottenbacher KJ, Ottenbacher ME, Ottenbacher AJ, et al. Androgen treatment and muscle strength in elderly men: a meta-analysis. J Am Geriatr Soc. 2006;54:1666–1673.

    PubMed  Article  Google Scholar 

  56. 56.

    Sih R, Morley JE, Kaiser FE, et al. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab. 1997;82:1661–1667.

    PubMed  Article  CAS  Google Scholar 

  57. 57.

    Page ST, Amory JK, Bowman FD, et al. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab. 2005;90:1502–1510.

    PubMed  Article  CAS  Google Scholar 

  58. 58.

    Bhasin S, Taylor WE, Singh R, et al. The mechanisms of androgen effects of body composition: mesenchymal pluripotent cellas the target of androgen action. J Gerontol A Biol Sci Med Sic. 2003;58:M1 103-M1110.

    Google Scholar 

  59. 59.

    Chapman IM. Anorexia abstracts, 4th Cachexia Conference. Tampa, Florida, March 1,2007. www.cachexia.org

  60. 60.

    Haren MT, Malmstrom TK, Banks WA, et al. Lower serum DHEAs levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women. Maturitas. 2007;57:347–360.

    PubMed  Article  CAS  Google Scholar 

  61. 61.

    Percheron G, Hogrel JY, Denot-Ledunois S, et al. Effect of 1-year oral administration of dehydroepiandrosterone to 60-to 80-year-old individuals on muscle function and cross-sectional area: a double-blind placebo-controlled trial. Arch Intern med. 2003;163:720–727.

    PubMed  Article  CAS  Google Scholar 

  62. 62.

    Frisoli A Jr., Chaves PH, Pinheiro MM, Szejnfeld VL. The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: a double-blind, randomized, placebo-controlled clinical trial. J Gerontol A Biol Sci Med Sci. 2005;60:648–653.

    PubMed  Google Scholar 

  63. 63.

    MacDonald JH, Marcora SM, Jibani MM, et al. Nandrolone decanoate as anabolic therapy in chronic kidney disease: a randomized phase II dose-finding study. Nephron Clin pract 2007;106:c125-c135.

    PubMed  Article  CAS  Google Scholar 

  64. 64.

    Gold J, Batterham MJ, Rekers H, et al. Effects of nandrolone decanoate compared with placebo or testosterone on HIV-associated wasting. HIV Med. 2006;7:146–155.

    PubMed  Article  CAS  Google Scholar 

  65. 65.

    Creutzberg EC, Wouters EF, Mostert R, et cl. A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest 2003;124:1733–1742.

    PubMed  Article  CAS  Google Scholar 

  66. 66.

    Gao W, Dalton JT, Ockham’s razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase? Mol Interv. 2007;7:10–13.

    PubMed  Article  CAS  Google Scholar 

  67. 67.

    Evans WJ, Smith M, Morley JE, et al. Ostarine increases lean body mass and improves physical performance in healthy elderly subjects: Implications for cancer cachexia patients. 2007 Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S):9119.

    Google Scholar 

  68. 68.

    Visser M, Deeg DJH, Lips P. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The Longitudinal Aging Study Amsterdam. J Clin Endocrin Metab. 2003;88:5766–5772.

    Article  CAS  Google Scholar 

  69. 69.

    Morley JE. Should all long-term care residents receive vitamin D? J Am Med Dir Assoc. 2007;8:69–70.

    PubMed  Article  Google Scholar 

  70. 70.

    Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: ameta-analysis. JAMA. 2004;291:1999–2006.

    PubMed  Article  CAS  Google Scholar 

  71. 71.

    Heath KM, Elovic EP. Vitamin D deficiency: implications in the rehabilitation setting. Am J Phys Med Rehabil. 2006;85:916–923.

    PubMed  Article  Google Scholar 

  72. 72.

    Perry HM 3rd, Horowitz M, Morley JE, et al. Longitudinal changes in serum 25-hydroxyvitamin D in older people. Metabolism. 1999;48:1028–1032.

    PubMed  Article  CAS  Google Scholar 

  73. 73.

    Drinka PJ, Krause PF, Nest LJ, Goodman BM. J Am Med Dir Assoc. 2007;8:76–79.

    PubMed  Article  Google Scholar 

  74. 74.

    Hamid Z, Riggs A, Spencer T, Redman C, Bodenner D. Vitamin D deficiency in residents of academic long-term care facilities despite having been prescribed vitamin D. J Am Med Dir Assoc. 2007;8:71–75.

    PubMed  Article  Google Scholar 

  75. 75.

    Munir J, Wright RJ, Carr DB. A quality improvement study on calcium and vitamin D supplementation in long-term care. J Am med Dir Assoc. 2006;7:305–309.

    PubMed  Article  Google Scholar 

  76. 76.

    Chu LW, Lam KS, Tarn SC et al. A randomized controlled trial of low-dose recombinant human growth hormone in the treatment of malnourished elderly medical patients: J Clin Endocrinol Metab. 2001;86:1913–1920.

    PubMed  Article  CAS  Google Scholar 

  77. 77.

    Kaiser FE, Silver AJ, Morley JE. The effect of recombinant human growth hormone on malnourished older individuals. J Am Geriatr Soc. 1991;39:235–240.

    PubMed  CAS  Google Scholar 

  78. 78.

    Morley JE. Growth hormone: fountain of youth or death hormone? J Am Geriatr Soc. 1999;47:1475–1476.

    PubMed  CAS  Google Scholar 

  79. 79.

    Gaskin FS, Farr SA, Banks WA, et al. Ghrelin-induced feeding is dependent on nitric oxide. Peptides. 2003;24:913–918.

    PubMed  Article  CAS  Google Scholar 

  80. 80.

    Diano S, Farr SA, Benoit SC, et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci. 2006;9:381–388.

    PubMed  Article  CAS  Google Scholar 

  81. 81.

    Nagaya N, Moriya J, Yasumura Y, et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation. 2004;110:3674–3679.

    PubMed  Article  CAS  Google Scholar 

  82. 82.

    Carter CS, Onder G, Kritchevsky SB, Pahor M. Angiotensin-converting enzyme inhibition intervention in elderly persons: effects on body composition and physical performance. J Gerontol A Biol Sci Med Sci. 2005;60:1437–1446.

    PubMed  Google Scholar 

  83. 83.

    Onder G, Vedova CD, Pahor M. Effects of ACE inhibitors on skeletal muscle. Curr Pharm Des. 2006;12:2057–2064.

    PubMed  Article  CAS  Google Scholar 

  84. 84.

    Frederiksen H, Bathum L, Worm C, et al. ACE genotype and physical training effects: a randomized study among elderly Danes. Aging Clin Exp Res. 2003;15:284–291.

    PubMed  CAS  Google Scholar 

  85. 85.

    Sumukadas D, Witham MD, Struthers AD, McMurdo ME. Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. CMAJ. 2007;177:867–874.

    PubMed  Google Scholar 

  86. 86.

    Hutcheon SD, Gillespie ND, Crombie IK, Struthers AD, McMurdo ME. Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a randomized double blind placebo controlled trial. Heart. 2002;88:373–377.

    PubMed  Article  CAS  Google Scholar 

  87. 87.

    Ferrucci L, Penninx BWJH, Volpato S, et al. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc. 2002;50:1947–1954.

    PubMed  Article  Google Scholar 

  88. 88.

    Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Ann Rev Med. 2000;51:245–270.

    PubMed  Article  CAS  Google Scholar 

  89. 89.

    Morley JE, Baumgartner RN. Cytokine-related aging process. J Gerontol A BIol Sci Med Sci. 2004;59:M924-M929.

    PubMed  Google Scholar 

  90. 90.

    McNally EM. Powerful genes—myostatin regulation of human muscle mass. N Engl J Med. 2004;350:2642–2644.

    PubMed  Article  CAS  Google Scholar 

  91. 91.

    Mazza AD, Morley JE. Metabolic syndrome and the older male population. Aging Male. 2007;10:3–8.

    PubMed  Article  CAS  Google Scholar 

  92. 92.

    Mazza AD, Morley JE. Update on diabetes in the elderly and the application of current therapeutics. J Am Med Dir Assoc. 2007;8:489–492.

    PubMed  Article  Google Scholar 

  93. 93.

    Patel S, Hyer S, Tweed K, et al. Risk factors for fractures and falls in older women with type 2 diabetes mellitus. Calcif Tissue Int 2008;82:87–91.

    PubMed  Article  CAS  Google Scholar 

  94. 94.

    Doherty TJ, Vandervoort AA, Brown WF. Effects of ageing on the motor unit: a brief review. Can J Appl Physiol. 1993;18:331–358.

    PubMed  CAS  Google Scholar 

  95. 95.

    Guillet C, Auguste P, Mayo W, et al. Ciliary neurotrophic factor is a regulator of muscular strength in aging. J Neurosci. 1999;19:1257–1262.

    PubMed  CAS  Google Scholar 

  96. 96.

    Morley JE, Patrick P, Perry HM 3rd. Evaluation of assays available to measure free testosterone. Metabolism. 2002;51:554–559.

    PubMed  Article  CAS  Google Scholar 

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Morley, J.E. Sarcopenia: Diagnosis and treatment. J Nutr Health Aging 12, 452 (2008). https://doi.org/10.1007/BF02982705

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Keywords

  • Testosterone
  • Muscle Mass
  • DHEA
  • Perindopril
  • Anabolic Steroid