W e report a patient with pseudo gray platelet syndrome. He was admitted to our hospital because of acute myocardial infarction. He had platelets that were stained poorly and appeared gray and agranular under a light microscope. This appear-ance is a characteristic feature of gray platelet syndrome. However, in this case, no bleeding tendency was observed and the abnormality was dependent on the presence of ethylenediamine tetra acetic acid (EDTA) and did not occur in a nonantico-agulant, trisodium citrate dihydrate and heparin. There are few reports of this pseudo gray platelet syndrome and, in fact, this is the first report of the syndrome in Japan, possibly because the phenomenon has been unrecognized and passed over in the past.Int J Hematol. 2002;76:376-378.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Raccuglia G. Grey platelet syndrome: a variety of qualitative platelet disorder.Am J Med. 1971; 51: 818–828.
Gerrard JM, Phillips DR, Rao GHR, et al. Biochemical studies of two patients with the gray platelet syndrome.J Clin Invest. 1980; 66: 102–109.
White JG. Ultrastructural studies of the gray platelet syndrome.Am J Pathol. 1979; 95: 455–462.
Rosa JP, George JN, Bainton DF, Nurden AT, Caen JP, McEver RP. Gray platelet syndrome:demonstration of alpha granule membranes that can fuse with the cell surface.J Clin Invest. 1987; 80: 1138–1146.
Mori K, Suzuki S, Sugai K. Electron microscopic and functional studies on platelets in gray platelet syndrome.Tohoku J Exp Med. 1984; 143: 261–287.
Cockbill SR, Burmester HBC, Heptinstall S. Pseudo grey platelet syndrome-grey platelets due to degranulation in blood collected into EDTA.Eur J Haematol. 1988; 41: 326–333.
Stavem P, Berg K. A macromolecular serum component acting on platelets in the presence of EDTA- ’platelet stain preventing factor.’Scand J Haematol. 1973; 10: 202–208.
Mant MJ, Doery JCG, Gauldie J, Sims H. Pseudothrombocytopenia due to platelet aggregation and degranulation in blood collected in EDTA.Scand J Haematol. 1975; 15: 161–170.
Onder O, Weinstein A, Hoyer LW. Pseudothrombocytopenia caused by platelet agglutinins that are reactive in blood anticoagulated with chelating agents.Blood. 1980; 56: 177–182
Bizzaro N. EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up.Am J Hematol. 1995; 50: 103–109.
Hoyt RH, Durie BG. Pseudothrombocytopenia induced by a monoclonal IgM kappa platelet agglutinin.Am J Hematol. 1989; 31: 50–52.
About this article
Cite this article
Toyota, S., Nakamura, N. & Dan, K. Pseudo Gray Platelet Syndrome in a Patient with Acute Myocardial Infarction. Int J Hematol 76, 376–378 (2002). https://doi.org/10.1007/BF02982700
- Pseudo gray platelet syndrome