International Journal of Hematology

, Volume 76, Issue 4, pp 349–353 | Cite as

Successful Treatment with Imatinib Mesylate of a CML Patient in Megakaryoblastic Crisis with Severe Fibrosis

  • Yuka Hirose
  • Hitoshi Kiyoi
  • Masanori Iwai
  • Toshiya Yokozawa
  • Masafumi Ito
  • Tomoki Naoe
Case Report


The prognosis of patients with chronic myeloid leukemia in blastic crisis (CML-BC) remains extremely poor, and multiagent chemotherapy regimens commonly used to treat acute leukemia offer only short-term benefits. Therefore, the advent of the novel molecularly targeted anticancer agent imatinib mesylate is a breakthrough in CML therapy. We present a CML patient in megakaryoblastic crisis with severe myelofibrosis, who was treated with imatinib at a dosage of 400 mg/day and achieved complete remission together with a marked regression of myelofibrosis after 1 month. The effect of imatinib on the long-term prognosis remains unclear, although the agent is clearly a promising drug for treating CML-BC even in cases of myelofibrosis.Int J Hematol. 2002; 76: 349-353.

Key words

Chronic myeloid leukemia Blastic crisis Myelofibrosis Imatinib mesylate Molecular targeted therapy 


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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Yuka Hirose
    • 1
  • Hitoshi Kiyoi
    • 1
  • Masanori Iwai
    • 1
  • Toshiya Yokozawa
    • 2
  • Masafumi Ito
    • 3
  • Tomoki Naoe
    • 1
  1. 1.Department of Infectious DiseasesNagoyaJapan
  2. 2.Department of Internal MedicineNagoya University School of MedicineNagoyaJapan
  3. 3.Department of PathologyNagoya University HospitalNagoyaJapan

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