International Journal of Hematology

, Volume 75, Issue 4, pp 426–433 | Cite as

Nationwide Study of Idiopathic Thrombocytopenic Purpura in Pregnant Women and the Clinical Influence on Neonates

  • Kingo Fujimura
  • Yuka Harada
  • Tetsuro Fujimoto
  • Atsushi Kuramoto
  • Yasuo Ikeda
  • Jun-ichi Akatsuka
  • Kazuo Dan
  • Mitsuhiro Omine
  • Hideaki Mizoguchi
Case Report


Idiopathic thrombocytopenic purpura (ITP) occurs more commonly in young women during the reproductive years. To obtain information for management of ITP in pregnancy, we performed a nationwide retrospective survey. Findings from a total of 284 pregnant women with ITP and their 286 newborn infants were available for analysis. The bleeding tendency at delivery was managed chiefly with corticosteroid, intravenous high-dose γulin, and platelet transfusion. Maternal complications occurred in 77 cases (27.1%) and were frequently seen in cases with poor control of ITP. Neonatal abnormalities, which were not influenced by the clinical state of the mother, occurred at a frequency of 17.8%. Thrombocytopenia in neonates occurred in 48 cases (22.4%), and bleeding tendency was found in 16 cases (6.3%) without severe bleeding. Prediction of thrombocytopenia in neonates was difficult. However, infants from splenectomized mothers with well-controlled ITP showed thrombocytopenia more frequently than those from nonsplenectomized mothers. Mothers treated with steroids at doses greater than 15 mg/day showed a high frequency of maternal complications and fetal abnormal body weight. These observations will be useful in the management of pregnant women with ITP and their infants.

Key words

ITP Pregnancy Maternal complication Fetal thrombocytopenia Corticosteroid treatment 


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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Kingo Fujimura
    • 1
  • Yuka Harada
    • 2
  • Tetsuro Fujimoto
    • 1
  • Atsushi Kuramoto
    • 2
  • Yasuo Ikeda
    • 3
  • Jun-ichi Akatsuka
    • 4
  • Kazuo Dan
    • 5
  • Mitsuhiro Omine
    • 6
  • Hideaki Mizoguchi
    • 7
  1. 1.Department of Clinical Pharmaceutical ScienceGraduate School of Medicine, Hiroshima UniversityMinami-ku,HiroshimaJapan
  2. 2.Department of Hematology/Oncology ,Research Institute for Radiation Biology and MedicinHiroshima UniversityHiroshima
  3. 3.Department of Internal MedicineKeio University School of MedicineTokyo
  4. 4.Department of PediatricsThe Jikei University School of MedicineTokyo
  5. 5.Department of Clinical HematologyNippon Medical SchoolTokyo
  6. 6.Division of HematologyShowa University Fujogaoka HospitalYokohama
  7. 7.Department of HematologyTokyo Women’s Medical University SchoolTokyoJapan

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