Advertisement

International Journal of Hematology

, Volume 75, Issue 3, pp 332–334 | Cite as

Ocular Manifestation of Acute Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation

  • Takashi Saito
  • Katsuji Shinagawa
  • Katsuto Takenaka
  • Keitaro Matsuo
  • Tadashi Yoshino
  • Katsuyuki Kiura
  • Kenji Niiya
  • Mine Harada
Case Report

Abstract

A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative.Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.

Key words

Pseudomembranous conjunctivitis Acute graft-versus-host disease Allogeneic peripheral blood stem cell transplantation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Harada M. Allogeneic peripheral blood stem cell transplantation is coming of age.Int J Hematol. 1998;62:1–5.Google Scholar
  2. 2.
    Russell NH, Gratwohl A, Schmitz N, et al. Developments in allogeneic blood progenitor cell transplantation.Br J Haematol. 1998;103:594–600.CrossRefGoogle Scholar
  3. 3.
    Janin A, Fagon T, Gastier P, et al. Pseudomembranous conjunctivitis following bone marrow transplantation: immunopathological and ultrastructural study of one case.Hum Pathol. 1996;27:307–309.CrossRefGoogle Scholar
  4. 4.
    Jabs DA, Wingard J, Green WR, et al. The eye in bone marrow transplantation, III: conjunctival graft-versus-host disease.Arch Ophthalmol. 1989;101:1343–1348.CrossRefGoogle Scholar
  5. 5.
    Przepiorka D, Weisdorf D, Martin P, et al. Consensus conference on acute GVHD grading.Bone Marrow Transplant. 1995;15:825–828.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Duke-Elder S. Inflammations of the conjunctiva and associated inflammations of the cornea. In: Duke-Elder S, ed.System of Ophthalmology: Diseases of the Outer Eye, pt 1. London: Henry Kimptom; 1977:90–92.Google Scholar
  7. 7.
    Hirst LW, Jabs DA, Tutschka MD, et al. The eye in bone marrow transplantation, I: clinical study.Arch Ophthalmol. 1983;101:580–588.CrossRefPubMedGoogle Scholar
  8. 8.
    Jack MK, Jack GM, Sale GE, et al. Ocular manifestations of graftversus-host disease.Arch Ophthalmol. 1983;101:1080–1084.CrossRefGoogle Scholar
  9. 9.
    Piguet PF, Janin A, Vassali P, et al. Epidermal lesions of the GVHR: evaluation of the role of different MHC and non MHC loci and of the Ly2+ and L3T4+ T lymphocytes.J Immunol. 1987;139:405–410.Google Scholar

Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Takashi Saito
    • 1
  • Katsuji Shinagawa
    • 1
  • Katsuto Takenaka
    • 1
  • Keitaro Matsuo
    • 1
  • Tadashi Yoshino
    • 2
  • Katsuyuki Kiura
    • 1
  • Kenji Niiya
    • 1
  • Mine Harada
    • 1
  1. 1.Second Department of Internal MedicineOkayama University Medical SchoolOkayamaJapan
  2. 2.Second Department of PathologyOkayama University Medical SchoolOkayamaJapan

Personalised recommendations