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International Journal of Hematology

, Volume 75, Issue 3, pp 314–317 | Cite as

T-Cell Prolymphocytic Leukemia With Hemorrhagic Gastrointestinal Involvement and a New Chromosomal Abnormality

  • Shigeo Toyota
  • Norihiko Nakamura
  • Kazuo Dan
Case Report

Abstract

We report a case of T-cell prolymphocytic leukemia in a 56-year-old woman who exhibited hemorrhaging with gastric involvement as the first manifestation. This patient’s condition was diagnosed as T-cell prolymphocytic leukemia based on the findings of lymphocytosis, abnormal immunophenotype, hepatosplenomegaly, lymphadenopathy, and cutaneous involvement. Endoscopic examination of the upper gastrointestinal tract revealed hemorrhage from a gastric lesion with histological involvement. Cytogenetic analysis revealed chromosomal abnormalities, 46,XX,der(1),add(1)(p36), that have not previously been described in T-cell prolymphocytic leukemia. In spite of a transient response to chemotherapy, the patient died 15 months after onset of the disease.

Key words

T-cell prolymphocytic leukemia Chromosomal abnormality Gastrointestinal involvement 

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References

  1. 1.
    Kojima K, Kobayashi H, Imoto S, et al. 14q11 abnormality and trisomy 8q are not common in Japanese T-cell prolymphocytic leukemia.Int J Hematol. 1998;68:291–296.CrossRefPubMedCentralPubMedGoogle Scholar
  2. 2.
    Matutes E, Brito-Babapulle V, Swansbury J, et al. Clinical and laboratory features of 78 cases of T-prolymphocytic leukemia.Blood. 1991;78:3269–3274.PubMedPubMedCentralGoogle Scholar
  3. 3.
    Matutes E, Garcia Talavera J, O’Brien M, Catovsky D. The morphological spectrum of T-prolymphocytic leukemia.Br J Haematol. 1986;64:111–124.CrossRefPubMedCentralPubMedGoogle Scholar
  4. 4.
    Matutes E, Catovsky D. Similarities between T-cell chronic lymphocytic leukemia and the small-cell variant of T-prolymphocytic leukemia.Blood. 1996;87:3520–3521.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Bennet JM, Catovsky D, Daniel MT, et al. Proposal for the classification of chronic (mature) B and T lymphoid leukemias.J Clin Pathol. 1989;42:567–584.CrossRefGoogle Scholar
  6. 6.
    Sakata H, Fujimoto K, Iwakiri R, et al. Gastric lesions in 76 patients with adult T-cell leukemia/lymphoma.Cancer. 1996;78:396–402.CrossRefPubMedCentralPubMedGoogle Scholar
  7. 7.
    Newland AC, Turnbull AL, Bainbridge D, Jenkins GC. Complete remission in T-cell prolymphocytic leukemia.Br J Haematol. 1980;45:513–514.CrossRefPubMedCentralPubMedGoogle Scholar
  8. 8.
    Zech L, Gahrton G, Hammarstrom L, et al. Inversion of chromosome 14 marks human T-cell chronic lymphocytic leukaemia.Nature. 1984;308:858–860.CrossRefPubMedCentralPubMedGoogle Scholar
  9. 9.
    Brito-Babapulle V, Pomfret M, Matutes E, Catovsky D. Cytogenetic studies on prolymphocytic leukemia, II:T cell prolymphocytic leukemia.Blood. 1987;70:926–931.PubMedPubMedCentralGoogle Scholar

Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Shigeo Toyota
    • 1
  • Norihiko Nakamura
    • 1
  • Kazuo Dan
    • 2
  1. 1.Department of Internal MedicineYokosuka Kyousai HospitalKanagawa
  2. 2.Third Department of Internal MedicineNippon Medical SchoolTokyoJapan

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