International Journal of Hematology

, Volume 75, Issue 3, pp 314–317 | Cite as

T-Cell Prolymphocytic Leukemia With Hemorrhagic Gastrointestinal Involvement and a New Chromosomal Abnormality

  • Shigeo Toyota
  • Norihiko Nakamura
  • Kazuo Dan
Case Report


We report a case of T-cell prolymphocytic leukemia in a 56-year-old woman who exhibited hemorrhaging with gastric involvement as the first manifestation. This patient’s condition was diagnosed as T-cell prolymphocytic leukemia based on the findings of lymphocytosis, abnormal immunophenotype, hepatosplenomegaly, lymphadenopathy, and cutaneous involvement. Endoscopic examination of the upper gastrointestinal tract revealed hemorrhage from a gastric lesion with histological involvement. Cytogenetic analysis revealed chromosomal abnormalities, 46,XX,der(1),add(1)(p36), that have not previously been described in T-cell prolymphocytic leukemia. In spite of a transient response to chemotherapy, the patient died 15 months after onset of the disease.

Key words

T-cell prolymphocytic leukemia Chromosomal abnormality Gastrointestinal involvement 


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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Shigeo Toyota
    • 1
  • Norihiko Nakamura
    • 1
  • Kazuo Dan
    • 2
  1. 1.Department of Internal MedicineYokosuka Kyousai HospitalKanagawa
  2. 2.Third Department of Internal MedicineNippon Medical SchoolTokyoJapan

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