International Journal of Hematology

, Volume 75, Issue 3, pp 298–301 | Cite as

Monitoring Minimal Residual Disease in patients With MLL-AF6 Fusion Transcript—Positive Acute Myeloid Leukemia Following Allogeneic Bone Marrow Transplantation

  • Hiroshi Takatsuki
  • Yuji Yufu
  • Yoshimichi Tachikawa
  • Naokuni Uike
Case Report

Abstract

Acute myeloid leukemia (AML) patients with chromosome 11q23 abnormalities or MLL rearrangements have a poor prognosis when treated with conventional chemotherapy. However, the efficacy of allogeneic bone marrow transplantation (BMT) for this type of leukemia is not yet clear.We describe 2MLL-AF6 fusion transcript-positive AML patients treated with allogeneic BMT who were monitored for minimal residual disease (MRD) by reverse transcriptase polymerase chain reaction. Although long survival or cure of this type of AML is rarely reported, 1 patient had durable remissions. Fusion transcripts disappeared in 1 patient but not in the other, even after the graft-versus-host disease effect was increased by the discontinuation of immmunosuppressive therapy. This is the first report of MRD and the probability of graft-versus-leukemia effects following BMT in AML patients who areMLL-AF6 fusion transcript positive.

Key words

MLL-AF6 fusion transcript Acute myeloid leukemia Allogeneic bone marrow transplantation 

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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Hiroshi Takatsuki
    • 1
  • Yuji Yufu
    • 1
  • Yoshimichi Tachikawa
    • 1
  • Naokuni Uike
    • 1
  1. 1.Department of HematologyNational Kyushu Cancer CenterFukuokaJapan

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