International Journal of Hematology

, Volume 75, Issue 2, pp 195–200 | Cite as

Successful Treatment of Nasal T-Cell Lymphoma With a Combination of Local Irradiation and High-Dose Chemotherapy

  • Takaomi Sanda
  • Shinsuke Iida
  • Masato Ito
  • Kazuya Tsuboi
  • Kazuhisa Miura
  • Shinsuke Harada
  • Hirokazu Komatsu
  • Atsushi Wakita
  • Hiroshi Inagaki
  • Ryuzo Ueda
Case Report


Nasal natural killer (NK)/T-cell lymphoma is characterized by an aggressive clinical course and poor prognosis. The term “NK/T-cell” lymphoma includes both the NK-cell type and the T-cell type, which are classified by immunophenotyping and according to T-cell receptor (TCR) rearrangement. In addition, CD56+ T-cell lymphoma is defined as NK-like T-cell lymphoma. This report concerns a 54-year-old woman with nasal T-cell lymphoma. Its phenotype showed pure T-cell type with CD3+, CD56, and TCR+ accompanied by Epstein-Barr virus infection. Although the lesions were localized in the nasal mucosa and facial skin (stage IE), local irradiation could not achieve complete remission (CR). We then administered 5 courses of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen followed by high-dose chemotherapy with an autologous peripheral blood stem cell transplantation. This therapy resulted in CR. Our results suggest that this lymphoma subtype may be cured by means of intensive treatment soon after diagnosis.

Key words

Nasal T-cell lymphoma Autologous peripheral blood stem cell transplantation Combined modality therapy Local irradiation 


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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Takaomi Sanda
    • 1
  • Shinsuke Iida
    • 1
  • Masato Ito
    • 1
  • Kazuya Tsuboi
    • 1
  • Kazuhisa Miura
    • 1
  • Shinsuke Harada
    • 1
  • Hirokazu Komatsu
    • 1
  • Atsushi Wakita
    • 1
  • Hiroshi Inagaki
    • 2
  • Ryuzo Ueda
    • 1
  1. 1.Second Department of Internal MedicineNagoya City University Medical SchoolNagoyaJapan
  2. 2.Second Department of PathologyNagoya City University Medical SchoolNagoyaJapan

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