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International Journal of Hematology

, Volume 75, Issue 2, pp 187–190 | Cite as

Acute Myelogenous Leukemia Concurrent With Untreated Chronic Lymphocytic Leukemia

  • Tsuyoshi Muta
  • Takashi Okamura
  • Yoshiyuki Niho
Case Report

Abstract

We report a case of acute myelogenous leukemia (AML) concurrent with untreated chronic lymphocytic leukemia (CLL). An 84-year-old Japanese man was admitted to the Chihaya Hospital with persistent high-grade fever. Morphologic observation of peripheral blood and bone marrow smears revealed a proliferation of blasts and lymphocytosis with small and mature phenotypes. Immunophenotyping of the blast cells revealed CD13+, CD33+, CD34+, and HLA-DR+, and that of the lymphocytes revealed CD5+, CD19+, CD20+, and λ+ on the cell surface. The peripheral lymphocytes revealed an IgH gene rearrangement. Chromosome analysis of 20 metaphase cells from bone marrow showed numerous abnormalities, containing +8,+11,+21. The patient’s disease was diagnosed as AML with trilineage dysplasia concurrent with CLL. The simultaneous occurrence of AML and CLL is extremely rare but should not be overlooked as a possible underlying cause of lymphocyte abnormalities in AML patients.

Key words

Chronic lymphocytic leukemia Acute myeloid leukemia Flow cytometry 

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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Tsuyoshi Muta
    • 1
  • Takashi Okamura
    • 2
  • Yoshiyuki Niho
    • 1
  1. 1.Department of Internal MedicineChihaya HospitalFukuoka City
  2. 2.Medicine and Biosystemic ScienceKyushu University Graduate School of Medical SciencesFukuoka CityJapan

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