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International Journal of Hematology

, Volume 75, Issue 1, pp 91–94 | Cite as

Plasma Thrombopoietin in Patients With Cavernous Transformation of the Portal Vein

  • Hakan Göker
  • Türker Egesel
  • Sema Karakuş
  • Ibrahim C. Haznedaroglu
  • Şule Apraş
  • Yahya Büyükaşik
  • Nilgün Sayinalp
  • Osman I. özcebe
  • Semra Dundar
  • Şerafettin Kirazli
  • Yusuf Bayraktar
Case Report

Abstract

Thrombopoietin (TPO), the primary regulator of thrombopoiesis, is produced mainly in the liver. Previous studies investigating blood TPO in chronic liver diseases revealed conflicting results. It has been suggested that hepatic TPO production is regulated by the portal blood supply to the liver. However, the role of TPO in the pathobiological basis of idiopathic portal vein thrombosis (PVT) and cavernous transformation of the portal vein (CTPV) has not been elucidated. The objective of this study is to assess plasma TPO concentrations in patients with CTPV. Eleven patients (4 men and 7 women, aged 38 ±12 years) with CTPV were studied. Sixteen healthy adults served as the control group (8 men and 8 women, aged 34 ±12 years). Median plasma TPO concentration was 326 pg/mL (range, 15-1402 pg/mL) in the patients with CTPV and 62.65 pg/mL (range, 38.5-102 pg/mL) in the control group (P = .003). In this study, we found significantly higher TPO concentrations in the plasma of patients with CTPV. The higher concentrations could be a result of the altered portal hemodynamics due to thrombosis. Moreover, TPO release by activated platelets might lead to the subsequent propagation of thrombosis in PVT.

Key words

Thrombopoietin Liver Portal vein thrombosis 

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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Hakan Göker
    • 1
  • Türker Egesel
    • 1
  • Sema Karakuş
    • 1
  • Ibrahim C. Haznedaroglu
    • 1
  • Şule Apraş
    • 1
  • Yahya Büyükaşik
    • 1
  • Nilgün Sayinalp
    • 1
  • Osman I. özcebe
    • 1
  • Semra Dundar
    • 1
  • Şerafettin Kirazli
    • 1
  • Yusuf Bayraktar
    • 1
  1. 1.Department of Internal MedicineHacettepe University Medical SchoolAnkaraTurkey

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