International Journal of Hematology

, Volume 75, Issue 1, pp 63–66 | Cite as

Philadelphia Chromosome-Positive Acute Myeloid Leukemia With Tetraploidy

  • Hiroki Yamaguchi
  • Koiti Inokuchi
  • Ena Yokomizo
  • Junko Miyata
  • Ayako Watanabe
  • Mituharu Inami
  • Kenji Tajika
  • Kazuo Dan
Case Report


The patient was a 62-year-old man. His hematological data in April 2000 had shown no abnormalities, but he was referred to our hospital because of a fever and leukocytosis in June 2000. The peripheral blood showed 29.8 X 109/L white blood cells, with 68.0% blasts. A bone marrow aspirate showed hypercellularity with a proliferation of large leukemic blasts. The leukemic cells were positive for CD13 (91%), CD33 (54.8%), CD34 (94.5%), and HLA-DR (97.9%). Some leukemic cells (15.6%) also expressed CD14. Cytogenetic analysis revealed 92,XXYY,t(9;22)(q34;q11)x2 in all 20 metaphase cells. Reverse transcriptase polymerase chain reaction analysis detected the minorBCR/ABL messenger RNA (mRNA) but failed to detect the majorBCR/ ABL mRNA. The patient achieved complete remission after induction chemotherapy, with no evidence of Philadelphia chromosome (Ph) or minorBCR/ABL mRNA. Ph-positive acute myeloid leukemia (Ph-AML) has rarely been reported. Herein, we report a case of Ph-AML with tetraploidy and review the previously reported Ph-AML cases.

Key words

Philadelphia chromosome Tetraploidy Acute myeloid leukemia 


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Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Hiroki Yamaguchi
    • 1
  • Koiti Inokuchi
    • 1
  • Ena Yokomizo
    • 1
  • Junko Miyata
    • 1
  • Ayako Watanabe
    • 1
  • Mituharu Inami
    • 1
  • Kenji Tajika
    • 1
  • Kazuo Dan
    • 1
  1. 1.Division of Hematology, Department of Internal MedicineNippon Medical SchoolTokyoJapan

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