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International Journal of Hematology

, Volume 73, Issue 3, pp 383–385 | Cite as

Analysis of Clonal Relationship Using Single-Cell Polymerase Chain Reaction in a Patient with Concomitant Mantle Cell Lymphoma and Multiple Myeloma

  • Motoko Yamaguchi
  • Toshiyuki Ohno
  • Eri Miyata
  • Hideki Toyoda
  • Kazuhiro Nishii
  • Masahiro Masuya
  • Kenkichi Kita
  • Hiroshi Shiku
Case Report

Abstract

We report a case of concomitant mantle cell lymphoma (MCL) and multiple myeloma (MM) in which we investigated the possibility of a clonal relationship. A 76-year-old man was diagnosed with MCL [immunoglobulin (Ig)M,D-K; stage IVB] and MM (IgG-K; stage I). Ig heavy chain (IgH) gene complementarity-determining region 3 in DNA from both the MCL tumor and from single MM cells from bone marrow smears was amplified to investigate whether there was a clonal relationship between MCL and MM. Sequence analysis revealed no clonal relationship between MCL and MM in our patient.

Key words

Mantle cell lymphoma Multiple myeloma Immunoglobulin heavy chain gene Clonality Single-cell PCR 

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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  • Motoko Yamaguchi
    • 1
  • Toshiyuki Ohno
    • 1
  • Eri Miyata
    • 1
  • Hideki Toyoda
    • 1
  • Kazuhiro Nishii
    • 1
  • Masahiro Masuya
    • 1
  • Kenkichi Kita
    • 1
  • Hiroshi Shiku
    • 1
  1. 1.Second Department of Internal MedicineMie University School of MedicineTsuJapan

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