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International Journal of Hematology

, Volume 73, Issue 2, pp 230–235 | Cite as

Concurrent Hodgkin’s Disease (Mixed Cellularity Type) and T-Cell Chronic Lymphocytic Leukemia/Prolymphocytic Leukemia

  • Akira Miyata
  • Kensuke Kojima
  • Tadashi Yoshino
  • Soichirou Fujii
  • Katsuji Shinagawa
  • Koichi Ichimura
Case Report

Abstract

We describe a patient with leukopenic T-cell chronic lymphocytic leukemia/prolymphocytic leukemia (T-CLL/PLL), according to the Revised European-American Classification of Lymphoid Neoplasms. This patient simultaneously developed classic Hodgkin’s disease (HD), a combination previously unreported. The leukemic cells were small and mature, did not have cytoplasmic granulation, and appeared similar to B-cell chronic lymphocytic leukemia. Immunophenotyping of the bone marrow—infiltrating cells revealed a postthymic suppressor/cytotoxic phenotype of CD2+, CD3+, CD4, CD5+, CD8+, CD25, TCR-α β. A lymph node biopsy showed the histological features of HD (mixed cellularity) with infiltrating CD8+ lymphocytes, and immunohistochemical examination revealed the following phenotype of Reed-Sternberg cells: LeuM1/CD15+, BerH2/CD30+, L26/PanB, UCHL-1/CD45RO, cyCD3, CD4, CD8, CD20, CD79a, EMA, EBER-1+, LMP-1+. Southern blot analysis of the bone marrow and lymph node revealed the same rearrangement of bands of T-cell-receptor genes. Although the HD was treated with chemotherapy that resulted in complete remission, the T-PLL/CLL took an indolent course. This case may suggest the existence of a subtype of T-CLL/PLL with leukopenia and an indolent clinical course. Both diseases were believed to be independent and not a transformation of one to the other.

Key words

T-cell chronic lymphocytic leukemia/prolymphocytic leukemia Hodgkin’s disease Leukopenia Indolent course 

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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  • Akira Miyata
    • 1
  • Kensuke Kojima
    • 2
  • Tadashi Yoshino
    • 3
  • Soichirou Fujii
    • 1
  • Katsuji Shinagawa
    • 4
  • Koichi Ichimura
    • 3
  1. 1.Department of Internal MedicineChugoku Central Hospital of the Mutual Aid Association of Public School TeachersHiroshima
  2. 2.Division of HematologyEhime Prefectural Central HospitalEhime
  3. 3.Second Department of PathologyOkayama University School of MedicineOkayama
  4. 4.Second Department of Internal MedicineOkayama University School of MedicineOkayamaJapan

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