International Journal of Hematology

, Volume 73, Issue 2, pp 222–225 | Cite as

Low Frequency ofBCL10 Gene Mutations in B-Cell Non-Hodgkin’s Lymphoma

  • Jiro Tadokoro
  • Yuichi Nakamura
  • Shinpei Furusawa
  • Kinuko Mitani
Case Report
  • 31 Downloads

Abstract

TheBCL10 gene was identified at the breakpoint region of the t(1;14)(p22;q32) translocation in mucosa-associated lymphoid tissue lymphoma. Initially, mutations in theBCL10 gene were reported to occur at a high frequency in various types of lymphomas and solid tumors. However, subsequent studies showed that the mutations were rarely recognized.To evaluate the frequency and spectrum of its mutations in B-cell non-Hodgkin’s lymphoma (B-NHL), we screened 56 cases with B-NHL by mutation analysis of exons 2 and 3 of the gene. In addition to 2 polymorphisms, a frame-shift mutation and a missense mutation were identified in 2 cases (3.6%): 1 with diffuse large B-cell lymphoma and the other with mantle cell lymphoma. Both cases showed mutations within exon 3, resulting in a C-terminal truncation in the former and a C-terminal amino acid substitution in the latter. Reverse transcriptase-polymerase chain reaction analysis of the former case revealed that both the mutated and the wild-type alleles were transcribed with or without a sequence modification. Our results, together with recent reports, indicate thatBCL10 gene mutations take place in a small population of B-NHL and are not associated with specific histological subtypes.

Key words

BCL10 gene Non-Hodgkin’s Lymphoma Mutations 

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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  • Jiro Tadokoro
    • 1
  • Yuichi Nakamura
    • 1
  • Shinpei Furusawa
    • 1
  • Kinuko Mitani
    • 1
  1. 1.Department of HematologyDokkyo University School of MedicineTochigiJapan

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