International Journal of Hematology

, Volume 73, Issue 2, pp 199–205 | Cite as

Effect of Granulocyte Colony-Stimulating Factor on Chemotherapeutic Activity of Cytosine Arabinoside in Acute Leukemic Cell Lines

  • Kwang Eun Cha
  • Soo Young Yoon
  • Kap No Lee
Review Article


Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on myeloid cell lines (HL-60 and KG-1).

Key words

Granulocyte colony-stimulating factor Cytosine arabinoside Leukemic cell lines Apoptosis 


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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  • Kwang Eun Cha
    • 1
  • Soo Young Yoon
    • 2
  • Kap No Lee
    • 2
  1. 1.Department of PediatricsCollege of Medicine, Pochon Cha UniversityPochon
  2. 2.Department of Clinical PathologyKorea University Medical SchoolSeoulKorea

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