International Journal of Hematology

, Volume 73, Issue 2, pp 170–176 | Cite as

The Pathogenesis of Chronic Myeloproliferative Diseases

  • Ayalew Tefferi
Review Article


Chronic myeloproliferative disorders are operationally classified to include essential thrombocythemia, polycythemia vera, and agnogenic myeloid metaplasia. In most cases, clonal hematopoiesis, involving all 3 myeloid lineages, can be demonstrated. However, the underlying molecular lesions that are responsible for disease initiation and progression remain elusive. There are ongoing efforts to clarify the pathogenetic role of cytokines, bone marrow stromal cells and molecules, and intracellular aberrations in either signal transduction or apoptosis. This review discusses some of the current and past observations regarding the pathogenesis of chronic myeloproliferative disorders.

Key words

Chronic myeloproliferative disease Essential thrombocythemia Polycythemia vera Agnogenic myeloid metaplasia 


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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  1. 1.Division of Hematology and Internal MedicineMayo Clinic and Mayo FoundationRochester

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