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Glucocorticoid-induced down regulation of transforming growth factor-β1 in adult rat lung fibroblasts

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Abstract

Transforming growth factor-β1 mRNA and transforming growth factor β activity are decreased with exposure of normal adult rat lung fibroblasts to dexamethasone. Dexamethasone caused a decrease in transforming growth factor-β1 mRNA within 2 hours, which was sustained at least over a 24-hour period. The decrease in transforming growth factor-β1 mRNA was dose related. Dexamethasone treatment of rat lung fibroblasts also resulted in a decrease of transforming growth factor β activity as determined by the mink lung cell growth inhibition assay. These data indicate that glucocorticoids may regulate collagen synthesis at least in part through the mediation of transforming growth factor-β1 in rat lung fibroblasts.

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Authors and Affiliations

  1. Department of Biochemistry, College of Medicine, University of Vermont, 05405, Burlington, VT

    S. Shull, N. Meisler & K. Cutroneo

  2. Department of Medicine, College of Medicine, University of Vermont, 05405, Burlington, VT

    M. Absher

  3. Department of Pathology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA

    S. Phan

Authors
  1. S. Shull
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  2. N. Meisler
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  3. M. Absher
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  4. S. Phan
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  5. K. Cutroneo
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Shull, S., Meisler, N., Absher, M. et al. Glucocorticoid-induced down regulation of transforming growth factor-β1 in adult rat lung fibroblasts. Lung 173, 71–78 (1995). https://doi.org/10.1007/BF02981467

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  • DOI: https://doi.org/10.1007/BF02981467

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