Abstract
The present study investigated the effects of gossypin, 3,3′,4′,5,7,8-hexahydroxyflavone 8-glu-coside, on the toxicity induced by oxidative stress or β-amyloid (Aβ) in primary cultured rat cortical cells. The antioxidant properties of gossypin were also evaluated by cell-free assays. Gossypin was found to inhibit the oxidative neuronal damage induced by xanthine/xanthine oxidase or by a glutathione depleting agent, D,L-buthionine (S,R)-sulfoximine. In addition, gossypin significantly attenuated the neurotoxicity induced by Aβ(25–35). Furthermore, gossypin dramatically inhibited lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. It also exhibited potent radical scavenging activity generated from 1,1-diphenyl-2-picrylhydrazyl. These results indicate that gossypin exerts neuroprotective effects in the cultured cortical cells by inhibiting oxidative stress- and Aβ-induced toxicity, and that the antioxidant properties of gossypin may contribute to its neuroprotective actions.
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Yoon, I., Lee, K.H. & Cho, J. Gossypin protects primary cultured rat cortical cells from oxidative stress- and β-amyloid-lnduced toxicity. Arch Pharm Res 27, 454–459 (2004). https://doi.org/10.1007/BF02980089
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DOI: https://doi.org/10.1007/BF02980089