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Antioxidant caffeic acid derivatives from leaves ofparthenocissus tricuspidata

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Abstract

Five caffeic acid derivatives; methyl ester of caffeoylglycolic acid (1), dimethyl ester of caffeoyltartaric acid (2), dimethyl ester of caffeoyltartronic acid (3), monomethyl ester of caffeoyltartronic acid (4), methyl ester of caffeic acid (5), and some other secondary metabolites including; quercetin, quercetin 3-O-β-D-glucuronide methyl ester, kaempferol, 3,5,7,4′-O-tetramethylkaempferol, β-sitosterol glucoside, 2α-hydroxyursolic acid and 2,24-dihydroxyursolic acid, have been isolated and characterized. All the isolated compounds were characterized with the help of NMR spectroscopy and mass spectrometry. Structure of compound3 was also confirmed by a single X-ray crystallographic technique. Isolates were evaluated for antioxidant activities and most of the tested compounds were found to be potent in DPPH free radical scavenging (IC50 = 4.56–14.17 μg/mL) and superoxide anion scavenging (IC50= 0.58–7.39 μg/mL) assays.

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Authors and Affiliations

  1. Medicinal Chemistry Research Center, Division of Life Sciences, Korea Institute of Science and Technology, P.O. Box 131, 130-650, Cheongryang, Seoul, Korea

    Muhammad Saleem, Hyoung Ja Kim, Changbae Jin & Yong Sup Lee

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  1. Muhammad Saleem
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  2. Hyoung Ja Kim
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  3. Changbae Jin
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  4. Yong Sup Lee
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Correspondence to Yong Sup Lee.

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Saleem, M., Kim, H.J., Jin, C. et al. Antioxidant caffeic acid derivatives from leaves ofparthenocissus tricuspidata . Arch Pharm Res 27, 300–304 (2004). https://doi.org/10.1007/BF02980064

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  • DOI: https://doi.org/10.1007/BF02980064

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