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Neoadjuvant and adjuvant chemotherapy in bladder cancer

Quimioterapia neoadyuvante y adyuvante en el cáncer de vejiga

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Abstract

State of the art treatment for invasive bladder cancer is cystectomy. Intensive clinical investigation has been performed in the last years about the role of neoadjuvant and adjuvant chemotherapy. Although neoadjuvant treatment seems not to increase long-term survival, it seems to play a role in the possibility of bladder preservation strategies. Adjuvant chemotherapy, in high-risk patients, seems to improve disease-free survival and time to progression. Nevertheless, new prospective studies should be performed to clarify its role in improving survival.

Resumen

Aunque el tratamiento estándar del carcinoma de vejiga infiltrante localizado es la cistectomía radical, durante la Última década se ha investigado intensamente el papel de la quimioterapia, administrada tanto de forma neoadyuvante como adyuvante. Aunque la quimioterapia neoadyuvante no parece haber obtenido un aumento de las tasas de supervivencia a largo plazo, puede permitir tratamientos locales menos agresivos con preservación funcional del órgano. La quimioterapia adyuvante, administrada en los pacientes que tras la cistectomía presentan factores de alto riesgo de recaída, parece que aumenta el intervalo libre de recaída y el tiempo a la progresión, aunque su contribución a una mejoría en la supervivencia debe aclararse llevando a cabo estudios prospectivos randomizados adecuados.

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  1. Servicio de Oncología Médica, Fundación Instituto Valenciano de Oncología, C./Profesor Beltrán Báguena, 9 y 19, 46009, Valencia

    Miguel A. Climent Durán & Vicente Guillem Porta

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  1. Miguel A. Climent Durán
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  2. Vicente Guillem Porta
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Durán, M.A.C., Porta, V.G. Neoadjuvant and adjuvant chemotherapy in bladder cancer. Rev Oncología 2, 231–237 (2000). https://doi.org/10.1007/BF02979562

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  • DOI: https://doi.org/10.1007/BF02979562

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