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Archives of Pharmacal Research

, Volume 18, Issue 2, pp 129–132 | Cite as

O-Acetyljervine: A new β-adrenoceptor agonist fromVeratrum album

  • Anwar H. Gilani
  • Khalid Aftab
  • S. A. Saeed
  • Rahat A. Ali
  • Atta-ur Rahman
Research Articles

Abstract

Intravenous administration ofO-acetyljervine (an alkaloid from Vertrum album) produced a dose-dependent (10–100 μg/kg) fall in blood pressure and tachycardia in anaesthetized normotensive rats. Pretreatment of animals with propranolol (1 mg/kg) abolished these cardiovascular responses ofO-acetyljervine similar to that of isoprenaline (1 μ/kg). In isolated tissue experiments,O-acetyljervine (10–100 μ/ml) produced a dose-dependent relaxation of phenylephrine-induced contraction of the rabbit aorta. In guinea-pig spontaneously beating atria, it caused positive inotropic and chronotropic responses in a dose-dependent fashion (10–100 μ/ml). These responses were abolished in the presence of propranolol (1 μg/ml) similar to that of isoprenaline. These results indicate thatO-acetyljervine is a adrenoceptor stimulant (β1 and β2) like isoprenaline.

Key words

O-acetyljervine Veratrum album β-adrenoceptor agonist Hypotensive Cardiac stimulant 

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Copyright information

© The Pharmaceutical Society of Korea 1995

Authors and Affiliations

  • Anwar H. Gilani
    • 1
  • Khalid Aftab
    • 2
  • S. A. Saeed
    • 1
  • Rahat A. Ali
    • 2
  • Atta-ur Rahman
    • 2
  1. 1.Department of PharmacologyThe Aga Khan Univeristy Medical CollegeKarachiPakistan
  2. 2.HEJ Research Institute of ChemistryUniversity of KarachiPakistan

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