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Stability of antineoplaston A10 in aqueous solution

Abstract

The analysis method and stability test of antineoplaston A10, a new anticancer drug candidate, were established. A10 and phenylacetyl- L-glutamine, one of the degradation products, can be detected by high-performance liquid chromatography. The degradation kinetics of antineoplaston A10 in aqueous solutions from pH 1 to 10 buffers were carried out at 40, 50 and 60°C. Pseudo-first order kinetics were obtained throughout the entire pH ranges studied. The pH-rate profiles showed that antineoplaston A10 was very unstable in alkaline conditions and most stable at pH4.

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Oh, I.J., Lee, J.M., Lee, Y.B. et al. Stability of antineoplaston A10 in aqueous solution. Arch. Pharm. Res. 18, 75–78 (1995). https://doi.org/10.1007/BF02979137

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  • DOI: https://doi.org/10.1007/BF02979137

Key words

  • Antineoplaston A10
  • Stability
  • Hydrolysis
  • Anticancer agent