Abstract
Antimicrobial activity of GL (the aqueous extract from the carpophores ofGanoderma lucidum (FR)KARST) was testedin vitro against Gram positive and Gram negative bacteria by serial broth dilution method, and the antimicrobial activity was expressed by minimal inhibitory concentration (MIC). Among fifteen species of bacteria tested, the antimicrobial activity of GL was the most potent againstMicrococcus luteus (MIC, 0.75 mg/ml). To investigate the effects of antimicrobial combinations of GL with four kinds of antibiotics (ampicillin, cefazolin, oxytetracycline and chloramphenicol), the fractional inhibitory concentration index (FICI) was determined by checkerboard assay for each strain. The antimicrobial combinations of GL with four antibiotics resulted in additive effect in most instances, synergism in two instances, and antagonism in two instances. Synergism was obvserved when GL was combined with cefazolin againstBacillus subtilis andKlebsiella oxytoca.
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Yoon, S.Y., Eo, S.K., Kim, Y.S. et al. Antimicrobial activity ofGanoderma lucidum extract alone and in combination with some antibiotics. Arch. Pharm. Res. 17, 438–442 (1994). https://doi.org/10.1007/BF02979122
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DOI: https://doi.org/10.1007/BF02979122