References Cited
Bauer, M. B., Murphy, S. and Gebhart, G. F., Stimulation of cyclic GMP production via a nitrosyl factor in sensory neuronal cultures by analgesic or inflammatory agents.J. Neurochem., 65, 363–372 (1995).
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D. and Julius, D., The capsaicin receptor: a heat-activated ion channel in the pain pathway.Nature, 389, 816–824 (1997).
Chard, P.S., Bleakman, D., Savidge, J. R. and Miller, R. J., Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases.Neuroscience, 65, 1099–1108 (1995).
Cholewinski, A., Burgess, G. M. and Bevan, S., The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons.Neuroscience, 55, 1015–1023 (1993).
Koh, J. Y. and Choi, D. W., Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay.J. Neurosci. Methods, 20, 83–90 (1987).
Nathan, C., Nitric oxide as a secretory product of mammalian cells.FASEB J., 6, 3051–3064 (1992).
Park, Y.-H., Surh, Y.-J. and Lee, S. S., Modulation by nitric oxide of capsaicin-induced calcium uptake into rat dorsal root ganglion neurons.Biochem. Mol. Biol. International, 47, 435–442 (1999).
Ren, K. and Ruda, M. A., Nitric oxide synthasecontaining neurons in sensory ganglia of the rat are susceptible to capsaicin-induced cytotoxicity.Neuroscience, 65, 505–511 (1995).
Sarih, M., Souvannavong, V. and Adam, A., Nitric oxide synthase induces macrophage death by apoptosis.Biochem. Biophys. Res. Commun., 191, 503–508 (1993).
Szallasi, A., The vanilloid (capsaicin) receptor: receptor types and species differences.Gen. Pharmac., 25, 223–243 (1994).
Tholey, G., Roth-Schechter, B. F. and Mandel, P., Activity and isoenzyme pattern of lactate dehydrogenase in neurons and astroblasts cultured from the brains of chick embryos.J. Neurochem., 36, 77–81 (1981).
Vizzard, M. A., Erdman, S. L. and de Groat, W. C., Increased expression of neuronal nitric oxide synthase (NOS) in visceral neurons after nerve injury.J. Neurosci., 15, 4033–4045 (1995).
Wood, J. N., Winter, J., James, I. F., Rang, H. P., Yeats, J. and Bevan, S., Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture.J. Neurosci., 8, 3208–3220 (1988).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Park, YH., Lee, SS. Nitric oxide mediates capsaicin-induced cytotoxicity in cultured dorsal root ganglion neurons. Arch Pharm Res 22, 432–434 (1999). https://doi.org/10.1007/BF02979072
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02979072