Abstract
A series of disubstituted 4,5-polymethylenepyrazoles were synthesized and evaluated their inhibitory activities against COX-2. Some compounds showed strong (0.3nM) inhibitory activity on COX-2 and were found somewhat selective (up to 16) on COX-2 over COX-1.
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Kim, H.H., Park, J.G., Moon, T.C. et al. Synthesis and biological activity of annulated pyrazoles as selective COX-2 inhibitors. I.. Arch Pharm Res 22, 372–379 (1999). https://doi.org/10.1007/BF02979060
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DOI: https://doi.org/10.1007/BF02979060