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Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique

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Abstract

A method was developed and fully validated for the determination of bevantolol, an adrenergic-receptor blocker, in human plasma. Bevantolol and betaxolol as internal standard (I.S) were extracted from 1mL of human plasma by solid phase extraction technique using Sep-pak silica cartridge. Chromatographic separation was accomplished under isocratic conditions using a reverse-phase C8 analytical column and mixture of dibasic ammonium phosphate (pH 5.7; 50mM)-acetonitrile (75:25, v/v) as mobile phase, with a detection wavelength at 220 nm. The method was proved to be specific by testing six different human plasma sources. Linearity was established for the concentration ranges of 40-1600 ng/mL with correlation coefficent of 0.9995. The lower limit of quantification 40 ng/mL with precision of 10.9% as C.V%.

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Authors and Affiliations

  1. Department of Biomedical Sciences, College of Medicine, Catholic University, 137-701, Seoul, Korea

    Ahmed M Al-Abd & Hyo Jeong Ku

  2. College of Pharmacy, Chungnam National University, 305-764, Daejeon, Korea

    Ho Yoon Lee & Sung Joo Hwang

  3. College of Pharmacy, Kangwon National University, 200-701, Chunchon, Korea

    Tran Quoc Trung, Pham Hai Long & Kyeong Ho Kim

Authors
  1. Tran Quoc Trung
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  2. Pham Hai Long
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  3. Ahmed M Al-Abd
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  4. Hyo Jeong Ku
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  5. Ho Yoon Lee
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  6. Sung Joo Hwang
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  7. Kyeong Ho Kim
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Correspondence to Kyeong Ho Kim.

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Trung, T.Q., Long, P.H., Al-Abd, A.M. et al. Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique. Arch Pharm Res 30, 890–897 (2007). https://doi.org/10.1007/BF02978842

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  • DOI: https://doi.org/10.1007/BF02978842

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