Résumé
A partir de trois cas d’œsophagite médicamenteuse dus au Bromure d’Emépronium survenus dans leur service et d’une revue de la casuistique mondiale portant sur une trentaine de cas environ, les auteurs tentent de mettre en lumière quelques caractéristiques de ce type d’œsophagite.
Elle touche des patients de tout âge, généralement sans pathologie œsophagienne préexistante pouvant expliquer un ralentissement anormal du transit, ayant le plus souvent avalé leur médicament au moment du coucher et à sec.
Bien que la symptomatologie soit toujours alarmante et douloureuse, les lésions évoluent dans leur grande majorité vers une guérison spontanée en quelques jours.
Les auteurs mettent aussi l’accent sur l’importance de la nature du médicament lui-même et émettent quelques considérations sur les mécanismes d’action lésionnels généralement invoqués.
Summary
From three cases of oesophagitis due to Emepronium Bromide which occurred in their department and a review of the world casuistics covering thirty-odd cases, the authors attempt to bring to light some clinical and anatomical characteristics of this type of oesophagitis.
It affects patients of all ages, generally without preexisting oesophageal pathology which could explain a slowing down of the transit; who most of the time had swallowed the drug without liquid at bed-time.
Although the symptoms are alays alarming and painful, the lesions progress on the whole toward spontaneous recovery within a few days. The authors also emphasize the importance of the nature of the drug itself and express a few considerations on the mecanism generally involved in the occurrence of the lesion.
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(Directeur: M. Savary)
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Guignard, A., Savary, M. L’œsophagite d’origine médicamenteuse. Acta Endosc 10, 263–272 (1980). https://doi.org/10.1007/BF02978269
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DOI: https://doi.org/10.1007/BF02978269