We studied the effect of aqueous extract ofMagnolia officinalis bark (Magnoliaceae) (MOAE) on the immediate hypersensitivity reaction. MOAE (0.01 to 1 g/kg) dose-depen-dently inhibited compound 48/80 induced systemic anaphylaxis in rats. MOAE (0.1 and 1 g/kg) also significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. When MOAE was pretreated at concentrations ranging from 0.01 to 1 g/kg, the levels of plasma histamine were reduced in a dose-dependent manner. MOAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) lgE. The level of cyclic AMP (cAMP) in RPMC, when MOAE was added, significantly increased compared with that of the normal control. Moreover, MOAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP lgE-induced tumor necrosis factor-α production from RPMC. These results indicate that MOAE inhibits immediate hypersensitivity reactionin vivo andin vitro.
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Shin, T.Y., Kim, D.K., Chae, B.S. et al. Antiallergic action of Magnolia officinalis on immediate hypersensitivity reaction. Arch Pharm Res 24, 249–255 (2001). https://doi.org/10.1007/BF02978266