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Antiallergic action of Magnolia officinalis on immediate hypersensitivity reaction

Archives of Pharmacal Research volume 24, pages 249–255 (2001)Cite this article

Abstract

We studied the effect of aqueous extract ofMagnolia officinalis bark (Magnoliaceae) (MOAE) on the immediate hypersensitivity reaction. MOAE (0.01 to 1 g/kg) dose-depen-dently inhibited compound 48/80 induced systemic anaphylaxis in rats. MOAE (0.1 and 1 g/kg) also significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. When MOAE was pretreated at concentrations ranging from 0.01 to 1 g/kg, the levels of plasma histamine were reduced in a dose-dependent manner. MOAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) lgE. The level of cyclic AMP (cAMP) in RPMC, when MOAE was added, significantly increased compared with that of the normal control. Moreover, MOAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP lgE-induced tumor necrosis factor-α production from RPMC. These results indicate that MOAE inhibits immediate hypersensitivity reactionin vivo andin vitro.

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Authors and Affiliations

  1. College of Pharmacy, Woosuk University, 565-701, Chonju, Chonbuk, Korea

    Tae Yong Shin & Dae Keun Kim

  2. College of Science and Engineering, Woosuk University, 565-701, Chonju, Chonbuk, Korea

    Byeong Suk Chae

  3. College of Oriental medicine, Wonkwang University, 570-749, Iksan, Chonbuk, Korea

    Eon Jeong Lee

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  1. Tae Yong Shin
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  2. Dae Keun Kim
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Correspondence to Tae Yong Shin.

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Shin, T.Y., Kim, D.K., Chae, B.S. et al. Antiallergic action of Magnolia officinalis on immediate hypersensitivity reaction. Arch Pharm Res 24, 249–255 (2001). https://doi.org/10.1007/BF02978266

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