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Cytotoxic constituents ofPsoralea corylifolia

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  • Pharmacology, Toxicology & Pharmaceutics
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Abstract

A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds ofPsoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 μg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates1–3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.

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References

  • Baskin, J. M., Ludlow, C. J., Harris, T. M., and Wolf, F. T. Psoralen, an inhibitor in the seeds ofPsoralea subacaulis.Phytochemistry, 6, 1209–1213 (1967).

    Article  CAS  Google Scholar 

  • Bensky, D. and Gamble, A. Chinese herbal medicine: Materia Medica. Revised edition. Eastland Press, Seattle, Washington, pp. 344–345 (1993).

    Google Scholar 

  • Inocenti, G., Cappelletti, E. M., and Caporale, G. Furocoumarin contents in the vegetative organs of cultivated Psoralea species.Int. J. Pharmacog., 29, 311–316 (1991).

    Article  Google Scholar 

  • Kondo, Y., Kato, A., Kubota, Y., and Nozoe, S. Bakuchicin, a new simple furanocoumarin fromPsoralea corylifolia.Heterocyles, 31, 187–190 (1990).

    Article  CAS  Google Scholar 

  • Mehta, G., Naysak, U. R., and Dev, S. Monoterpenoids. I.Psoralea corylifolia Linn. 1. bakuchiol, a novel monoterpene phenol.Tetrahedron 29, 1119–1125 (1973).

    Article  CAS  Google Scholar 

  • Miura, H., Nishida, H., and Iinuma, M. Effect of crude fractions ofPsoralea corylifolia seed extract on bone calcification.Planta Med. 62, 150–153 (1996).

    Article  PubMed  CAS  Google Scholar 

  • Ryu, S. Y., Choi, S.U., Lee, C. C., and Zee, O. P. Antitumor activity ofPsoralea corylifolia.Arch. Pharm. Res., 15, 356–359 (1992).

    Article  CAS  Google Scholar 

  • Tsai, W. J., Hsin, W. C., and Chen, C. C. Antiplatelet flavonoids from seeds ofPsoralea corylifolia.J. Nat. Prod., 59, 671–672 (1996).

    Article  PubMed  CAS  Google Scholar 

  • Yang, Y. -M., Hyun, J. -W., Sung, M. -S., Chung, H. -S., Kim, B. -K., Paik, W.-H., Kang, S. -S., and Park, J.-G. The cytotoxicity of Psoralidin fromPsoralea corylifolia.Planta Med., 62, 353–354 (1996).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Natural Products Research Institute, Seoul National University, 110-460, Seoul, Korea

    Woongchon Mar & Kang-Hun Je

  2. Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University, 120-750, Seoul, Korea

    Eun-Kyoung Seo

Authors
  1. Woongchon Mar
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  2. Kang-Hun Je
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  3. Eun-Kyoung Seo
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Correspondence to Eun-Kyoung Seo.

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Mar, W., Je, KH. & Seo, EK. Cytotoxic constituents ofPsoralea corylifolia . Arch Pharm Res 24, 211–213 (2001). https://doi.org/10.1007/BF02978259

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  • DOI: https://doi.org/10.1007/BF02978259

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