Abstract
Various analogues of 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) such as 2- or 6-(1-hydroxyiminoalkyl)-DMNQs were prepared and evaluated for the antitumor action. (1-Hydroxyiminoalkyl)-DMNQ derivatives expressed greater antitumor action than (1-hydroxy-alkyl)- or acyl-DMNQ derivatives. Moreover, 6-(1-hydroxyiminoalkyl)-DMNQ derivatives expressed higher antitumor action than 2-sudstituted ones, suggestive of a steric effect. Some of 6-(1-propyloxyalkyl)-DMNQ derivatives with an alkyl group of butyl to octyl moiety showed T/C values of >400%
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Song, GY., Kim, Y., You, YJ. et al. Naphthazarin derivatives (VII): antitumor action against ICR mice bearing ascitic S-180 cells. Arch Pharm Res 24, 190–193 (2001). https://doi.org/10.1007/BF02978254
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DOI: https://doi.org/10.1007/BF02978254