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Synthesis, Analgesic, and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-Chloropyrazole-1-yl)-3(2H)-Pyridazinon-2-yl]Acetamides

Abstract

A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.

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Correspondence to Murat Süküroglu, Burcu Çaliskan Ergün, Serdar ünlü, M. Fethi Sahin, Esra Küpeli, Erdem Yesilada or Erden Banoglu.

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Süküroglu, M., Ergün, B.Ç., ünlü, S. et al. Synthesis, Analgesic, and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-Chloropyrazole-1-yl)-3(2H)-Pyridazinon-2-yl]Acetamides. Arch Pharm Res 28, 509–517 (2005). https://doi.org/10.1007/BF02977751

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Keywords

  • Pyridazinone
  • Pyrazole
  • Analgesic
  • Anti-Inflammatory
  • Writhing
  • Carrageenan