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Cyanoacetic acid hydrazide in heterocyclic synthesis: A new route for the synthesis of several annelated pyran derivatives

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Abstract

Cyanoacetic acid hydrazide reacted with some 2-pyrazolin-5-one, isoxazol-5-one and 2-thiazolin-4-one and their ylidene derivatives to yield several new annelated pyran heterocycles. Structures were established on the basis of elementary analyses and spectral data studies in addition to synthesis via other routes.

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References Cited

  • Anrep, G. V., Barsou, G. S. and Kenawy, M. R., Pharmacological actions of the crystalline principles of Ammi visnaga,J. Pharm. Pharmacol., 1, 164–76 (1949).

    PubMed  CAS  Google Scholar 

  • Cremlyn, R., Pesticides, Preparation and Mode of Action, John Wiley and Sons, Inc., New York, 1978.

    Google Scholar 

  • Elnagdi, M. H., Elmoghayar, M. R. H. and Elghandour, A. H. H., The reaction of thioglycolic acid with α, β-unsaturated nitriles: A new route for the synthesis of 7H-thiazolo[3, 2-a]pyridines,Sulfur Lett. 9, 109–122 (1989).

    CAS  Google Scholar 

  • Hori, M. and Ito, E., Inhibitory effects of antitumor substances on growth and glycolysis of yoshida rat sarcoma cells,J. Antibiot., 17A, 96–102 (1964).

    Google Scholar 

  • Makie, A. and Mirsa, A. L., Preparation of rhodanine derivatives as possible anthelmintics,J. Chem. Soc., 3919–3922 (1954).

  • Mitzger, J. V., Thiazole and its Derivatives, John Wiley and Sons, New York, 1979.

    Google Scholar 

  • Mostafa, A., Asker, W., Khatattab, S., Sobhy, M. E. E., Fleifil, A. M. and Abu-Elazayem, K., Action of Grignard reagents XVII: Action of organomagnesium compounds on 5-arylidene derivatives of 3-arylrhodanine-3(2H)-4, 5-benzothianaphthenes,J. Amer. Chem. Soc., 82, 2029–2032 (1960).

    Article  Google Scholar 

  • Rich, S., Fungicidal chemistry in plant pathology, Horsfall, J. G. and Diamond, A. (Eds.), Academic Press, New York, 1960, pp. 588–595.

    Google Scholar 

  • Townsend, L. B. and Robines, R. K., Ring cleavage of purine nucleosides to yield possible biogenetic precursors of pteridines and riboflavins,J. Amer. Chem. Soc., 85, 242–243 (1963).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pesticidal Chemistry, National Research Center, Tahrir Street, Dokki, Giza, A. R. Egypt

    Sanaa M. Eldin, Asmaa A. Magd El-Din & Wahid M. Basyouni

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  1. Sanaa M. Eldin
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  2. Asmaa A. Magd El-Din
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  3. Wahid M. Basyouni
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Eldin, S.M., El-Din, A.A.M. & Basyouni, W.M. Cyanoacetic acid hydrazide in heterocyclic synthesis: A new route for the synthesis of several annelated pyran derivatives. Arch. Pharm. Res. 16, 318–321 (1993). https://doi.org/10.1007/BF02977523

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  • DOI: https://doi.org/10.1007/BF02977523

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