New anti-inflammatory formulation containingSynurus deltoides extract

  • Yong Hwan Choi
  • Kun Ho Son
  • Hyeun Wook Chang
  • KiHwan Bae
  • Sam Sik Kang
  • Hyun Pyo KimEmail author
Articles Drug Efficacy


Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activityin vivo. In this study, new anti-inflammatory formulation containingS. deltoides extract as a major ingredient was prepared andin vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part ofS. deltoides extract, 0.9 part ofAngelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1% inhibition of AA-induced ear edema at an oral dose of, 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7-day model of multiple treatment of TPA (38.1% inhibition at 200 mg/kg/day). Furthermore, SAG (50–800 mg/kg/day) as well asS. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin E2 production from the skin lesion of the animals of 7-day model. These results were well correlated within vitro finding that SAG as well asS. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. There-fore, these results suggest that SAG possesses anti-inflammatory activityin vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed byS. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.

Key words

Synurus deltoides Aiton Nakai Angelica gigas Nakai Glucosamine sulfate Anti-inflammatory activity Cyclooxygenase Prostaglandin 


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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Yong Hwan Choi
    • 5
  • Kun Ho Son
    • 1
  • Hyeun Wook Chang
    • 2
  • KiHwan Bae
    • 3
  • Sam Sik Kang
    • 4
  • Hyun Pyo Kim
    • 5
    Email author
  1. 1.Dept. Food NutrAndong National UniversityAndongKorea
  2. 2.College of PharmacyYeungnam UniversityGyongsanKorea
  3. 3.College of PharmacyChungnam National UniversityDaejeonKorea
  4. 4.Natural Products Research InstituteSeoul National UniversitySeoulKorea
  5. 5.College of PharmacyKangwon National UniversityChunchonKorea

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