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Synthesis and antifungal activity of naphthalene-1,4-diones modified at positions 2, 3, and 5

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Abstract

A series of 2-arylamino-5-hydroxy-naphthalene-1,4-diones, 3-arylamino-5-methoxy-naphthalene-1,4-diones, and 2-arylamino-3chloro-5-hydroxy-naphthalene-1,4-diones were synthesized and tested forin vitro antifungal activity against the speciesCandida andAspergillus niger. Among those tested, 3-arylamino-5-methoxy-naphthalene-1,4-diones exhibited potent antifungal activity. In general, the 3-arylamino-5-methoxy-naphthalene-1,4-diones showed more potent antifungal activity than the 2-arylamino-5-hydroxy-naphthalene-1,4-diones and the 2-arylamino-3-chloro-5-hydroxy-naphthalene-1,4-diones.

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Authors and Affiliations

  1. College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, 120-750, Seoul, Korea

    Chung-Kyu Ryu & Mi Jin Chae

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  1. Chung-Kyu Ryu
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  2. Mi Jin Chae
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Correspondence to Chung-Kyu Ryu.

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Ryu, CK., Chae, M.J. Synthesis and antifungal activity of naphthalene-1,4-diones modified at positions 2, 3, and 5. Arch Pharm Res 28, 750–755 (2005). https://doi.org/10.1007/BF02977337

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  • DOI: https://doi.org/10.1007/BF02977337

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