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The radical scavenging effects of stilbene glucosides fromPolygonum multiflorum

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The extract of the root ofPolygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activityin vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4′-tetrahydroxystilbene-2-0-²-d-glucopyra-noside (1) as an active constituent responsible for the antioxidant property. Compound1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 μM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 μM).

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Correspondence to Byoung Wook Choi.

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Ryu, G., Ju, J.H., Park, Y.J. et al. The radical scavenging effects of stilbene glucosides fromPolygonum multiflorum . Arch Pharm Res 25, 636–639 (2002).

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