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The radical scavenging effects of stilbene glucosides fromPolygonum multiflorum

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Abstract

The extract of the root ofPolygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activityin vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4′-tetrahydroxystilbene-2-0-²-d-glucopyra-noside (1) as an active constituent responsible for the antioxidant property. Compound1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 μM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 μM).

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References

  • Aue, W. P., Bartholdi, E., Ernst, R. R., Two dimensional spectroscopy. Application to nuclear magnetic resonance.J. Chem. Phys., 64, 2229–2246 (1976).

    Article  CAS  Google Scholar 

  • Bax, A.; Subramanian, S., Sensitivity-enhanced four-dimensional hetero nuclear shift correlation NMR spectroscopy.J. Magn. Res., 67, 565–569 (1986).

    CAS  Google Scholar 

  • Bax, A., Summer, M. R., Proton and carbon-13 assignments from multiple-bond connectivity by 2D multiple quantum NMR.J. Am. Chem. Soc., 108, 2093–2094 (1986).

    Article  CAS  Google Scholar 

  • Bouchet, N., Barrier, L., Fauconneau, B., Radical scavenging activity and antioxidant properties of tannins fromGuiera senegalensis (Combretaceae),Phytother. Res., 12, 159–162 (1998)

    Article  CAS  Google Scholar 

  • Chen, C.-C., Wu, L.-G., Ko, F.-N., Teng, C.-M., Antiplatelet aggregation principles o.Dendrobium loddigesii, J. Nat. Prod., 57, 1271–1274 (1994).

    CAS  Google Scholar 

  • Chen, J. H., Ho, C.-T., Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds.J. Agric. Food Chem., 45, 2374–2378 (1997).

    Article  CAS  Google Scholar 

  • Frankel, E. N., Waterhouse, A. L., Kinsella, J. E., Inhibition of human LDL oxidation by resveratrol.Lancet, 341, 1103–1104 (1993).

    Article  PubMed  CAS  Google Scholar 

  • Geahlen, R. L., Piceatannol(3,4,3′,5′-tetahydroxy-frans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor,Biochem. Biophys. Res. Commmun., 165, 241–245 (1989).

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, D. M., Does wine work.Clini. Chem., 41, 14–16 (1995).

    CAS  Google Scholar 

  • Hata, K., Kozawa, M., Baba, K., New stilbene glucose Chinese crude dru.Heshouwu root ofPoloygonum multiflorm, Yakugaku Zasshi, 95, 211–213 (1975).

    CAS  Google Scholar 

  • Inamori, Y., Kubo, M., Tsujibo, H., Ogawa, M., Saito, Y., Miki, Y., Takemura, S., The ichthyotoxicity and cornary vasodilator action of 3,3’-diethylstilbene.Chem. Pharm. Bull., 35, 887–890 (1989).

    Google Scholar 

  • Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. S., Famsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., Pezzuto, J. M., Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.Science, 275, 218–220 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Jayatilake, G. S., Jayasuriya, H., Lee, E.-S., Koonchanok, N. M., Geahlen, R. L., Ashendel, C. L., McLaughlin, J. L., Chang, C. J., Kinase inhibitors fro.Polygonum cuspidatum, J. Nat. Prod., 56, 1805–1810 (1993).

    Article  CAS  Google Scholar 

  • Langcake, P., Corngird, C. A., Pryce, R. J., Identification of pterostilbene as pyhtoalexin fro.Vitis vinifera leaves,Phytochem., 18, 1025–1027 (1979).

    Article  CAS  Google Scholar 

  • Mannila, E., Talvitie, A., Kolehmainen, E., Antileukemic compounds derived from stilbene i.Picea abies bark,Phytochem., 33, 813–816 (1993).

    CAS  Google Scholar 

  • Mattivi, F., Reniero, R., Korhammer, S., Isolation, characterization, and evolution in red wine vinification of resveratrol monomers.J. Agric. Food Chem., 43, 1820–1823 (1995).

    Article  CAS  Google Scholar 

  • Murakami, S., Arai, I., Muramatsu, M., Otomo, S., Baba, K., Kido, T., Kozawa, M., Effect of stilbene derivatives on gastric H+,T+-ATPase,Biochem. Pharmacol., 44, 1947–1951 (1992).

    Article  PubMed  CAS  Google Scholar 

  • Nyemba, A. M., Mpondo, N. T., Kimbu, S. R., Connolly, J. D., Stilbene glycosides fro.Guibourtia Tessmannii, Phytochem., 39, 895–898 (1995).

    Article  CAS  Google Scholar 

  • Oliver, J. M., Burg, D. L., Wilson, B. S., McLaughlin, J. I., Inhibition of mast-cell FC-ε-RI-mediated signaling and effector function by the SYK selective inhibitor, piceatannol.J. Biol. Chem., 269, 29697–29703 (1994).

    PubMed  CAS  Google Scholar 

  • Orsini, R., Pelizzoni, R., Verotta, L., Aburjai, T., Rogers, C. B., Isolation, synthesis, and antiplatelet aggregation activity of resveratrol-3-O-β-glucoside and related compounds.J. Nat. Prod., 60, 1082–1087 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Pietta, P., Simonetti, P., Mauri, P., Antioxidant activity of selected medicinal plants.J. Agric. Food Chem., 46, 4487–4490 (1998).

    Article  CAS  Google Scholar 

  • Rice-Evans, C. A., Miller, N. J., Bolwell, P. G., Brmaley, P. M., Pridham, J. B., The relative antioxidant activity of plant-derived polyphenolic flavonids.Free Rad. Res., 22, 375–383 (1995).

    Article  CAS  Google Scholar 

  • Ryu, G., Park, E. K., Joo, J. H., Lee, B. H., Choi, B. W., Jung, D. S., Lee, N. H., A new antioxidant monoterpene glycoside, á- benzoyloxypaeoniflorin fro.Paeonia suffruticosa, Arch. Pharm. Res., 24, 105–108 (2001).

    CAS  Google Scholar 

  • Ryu, S. Y., Han, Y. N., Han B. H., Monoamine oxidase-A inhibitors from medicinal plants.Arch. Pharm. Res., 11, 230–239 (1988).

    Article  CAS  Google Scholar 

  • Teguo, P. W., Decendit, A., Vercauteren, J., Deffieux, G., Merillon, J. M., Transresreratrol-3-O-β-glucose (piceid) in cell suspension cultures ofVitis vinifera, Phytochem., 42, 1591–1593 (1996).

    Article  CAS  Google Scholar 

  • Teguo, P. W., Decendit, A., Krisa, S., Vercauteren, J., Deffieux, G., Merillon, J. M., The accumulation of stilbene glycosides i.Vitis vinifera cell suspension cultures ofVitis vinifera, J. Nat. Prod., 59, 1189–1191 (1996).

    Article  CAS  Google Scholar 

  • Teguo, P. W., Deffieux, G., Vercauteren, J., Merillon, J. M., Isolation, identificaion, and antioxidant activity of three stilbene glucosides newly extracted fro.Vitis vinifera cell cultures,J. Nat. Prod., 61, 655–657 (1998).

    CAS  Google Scholar 

  • Thakkar, K., Geahlen, R. L., Cushman, M., Synthesis and protein-tyrosine kinase inhibitory activity of polyhyroxylated stilbene analogs of piceatannol.J. Med. Chem., 36, 2950–2955 (1993).

    Article  PubMed  CAS  Google Scholar 

  • Verotta, L., Rogers, B. C., Aburjai, T., Cignarella, A., Colli, S., Puglisi, L., Giomate di Chimica delle Sostanze Naturali, III convegno Nazionale, Amalfi (SA) 29 maggio-1 giugno, 3 (1994).

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Correspondence to Byoung Wook Choi.

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Ryu, G., Ju, J.H., Park, Y.J. et al. The radical scavenging effects of stilbene glucosides fromPolygonum multiflorum . Arch Pharm Res 25, 636–639 (2002). https://doi.org/10.1007/BF02976935

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  • DOI: https://doi.org/10.1007/BF02976935

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