Skip to main content
Log in

Synthesis and antitumor activity of cannabigerol

  • Research Articles
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration (IC50)=31.3l μ/mL]in vitro assay.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References Cited

  • Baek, S. H., Yook, C. N. and Han, D. S.: Boron trifluoride etherate on alumina-A modified Lewis acid reagent(V). A convenient single step synthesis of cannabinoids.Bull. Kor. Chem. Soc. 16(3), 293–296 (1991).

    Google Scholar 

  • Baek, S. H., Srebnik, M., and Mechoulam, R.: Boron trifluoride etherate on alumina-A modified Lewis acid reagent. An improved synthesis of cannabidiol.Tetrahedron Lett. 26(8), 1083–1086 (1985).

    Article  CAS  Google Scholar 

  • Baik, K. U., and Ahn, B. Z.: Cyctotoxic activities of some geranylated flavones against L 1210 cell.J. Pharm. Soc. Korea, 32(2), 125–128 (1988).

    CAS  Google Scholar 

  • colasanti, B. K., and Gong, H., Marihuana 87, Chesher, G.; Consroe, P.; Musty, R. Ed., Australian Government Publishing Service, Canberra, pp. 119–124 (1988).

    Google Scholar 

  • Carmichael, J., Degraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B., Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing.Cancer Res. 47, 936–942 (1987).

    PubMed  CAS  Google Scholar 

  • Dewey, W. L.: Cannabinoid pharmacology.Pharmacol. Rev., 38, 151–178 (1986).

    PubMed  CAS  Google Scholar 

  • Kleinman, S., Weitzman, S. A., Cassem, N., and Andrews, E.: Double blind trial of δ-9-tetrahydrocannabinol (THC) as an adjunct to prochlorperazine for chemotherapy-induced vomiting.Curr. Ther. Res. 34, 1014–1017 (1983).

    Google Scholar 

  • Kang, K. S., Ryu, S. H., and Ahn, B. Z.: Antineoplastic natural products and the analogues VI.Arch. Pharm. Res. 8, 187–190 (1985).

    Article  Google Scholar 

  • Mechoulam, R.: In Cannabinoids as therapeutic agents, Boca Raton, CRC Press Inc., (1986).

    Google Scholar 

  • Mosmann, T. J.:Rapid colorimetric assays for cellular growth and survival: application to proliferation and cytotoxicity assays.Immunol. Methods, 65, 55–63 (1983).

    Article  CAS  Google Scholar 

  • McCabe, M., Smith, F. P., Macdonald, J. S., and Woolley, P. V.:Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy.Invest. New Drugs. 6, 243–246 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Plasse, T. F., Gorter, R. W., Krasnow, S. H., Lane, M., Shepard, K. V., and Wadleig, H. R. G.: Recent clinical experince with dronabinol.Pharmacol. Biochem. Behav. 40, 695–700 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Sallan, S. E., Cronin, C., Zelen, M., and Zinberg, N. E.: Antiemetics in patients receiving chemotherapy for cancer: A randomized comparison of δ-9-tetrahydrocannabinol and prochlorperazine.N. Engl. J. Med. 302, 135–138 (1980).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baek, SH., Du Han, S., Yook, C.N. et al. Synthesis and antitumor activity of cannabigerol. Arch. Pharm. Res. 19, 228–230 (1996). https://doi.org/10.1007/BF02976895

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02976895

Key words

Navigation