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Synthesis and antitumor activity of cannabigerol


Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration (IC50)=31.3l μ/mL]in vitro assay.

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References Cited

  • Baek, S. H., Yook, C. N. and Han, D. S.: Boron trifluoride etherate on alumina-A modified Lewis acid reagent(V). A convenient single step synthesis of cannabinoids.Bull. Kor. Chem. Soc. 16(3), 293–296 (1991).

    Google Scholar 

  • Baek, S. H., Srebnik, M., and Mechoulam, R.: Boron trifluoride etherate on alumina-A modified Lewis acid reagent. An improved synthesis of cannabidiol.Tetrahedron Lett. 26(8), 1083–1086 (1985).

    Article  CAS  Google Scholar 

  • Baik, K. U., and Ahn, B. Z.: Cyctotoxic activities of some geranylated flavones against L 1210 cell.J. Pharm. Soc. Korea, 32(2), 125–128 (1988).

    CAS  Google Scholar 

  • colasanti, B. K., and Gong, H., Marihuana 87, Chesher, G.; Consroe, P.; Musty, R. Ed., Australian Government Publishing Service, Canberra, pp. 119–124 (1988).

    Google Scholar 

  • Carmichael, J., Degraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B., Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing.Cancer Res. 47, 936–942 (1987).

    PubMed  CAS  Google Scholar 

  • Dewey, W. L.: Cannabinoid pharmacology.Pharmacol. Rev., 38, 151–178 (1986).

    PubMed  CAS  Google Scholar 

  • Kleinman, S., Weitzman, S. A., Cassem, N., and Andrews, E.: Double blind trial of δ-9-tetrahydrocannabinol (THC) as an adjunct to prochlorperazine for chemotherapy-induced vomiting.Curr. Ther. Res. 34, 1014–1017 (1983).

    Google Scholar 

  • Kang, K. S., Ryu, S. H., and Ahn, B. Z.: Antineoplastic natural products and the analogues VI.Arch. Pharm. Res. 8, 187–190 (1985).

    Article  Google Scholar 

  • Mechoulam, R.: In Cannabinoids as therapeutic agents, Boca Raton, CRC Press Inc., (1986).

    Google Scholar 

  • Mosmann, T. J.:Rapid colorimetric assays for cellular growth and survival: application to proliferation and cytotoxicity assays.Immunol. Methods, 65, 55–63 (1983).

    Article  CAS  Google Scholar 

  • McCabe, M., Smith, F. P., Macdonald, J. S., and Woolley, P. V.:Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy.Invest. New Drugs. 6, 243–246 (1988).

    PubMed  Article  CAS  Google Scholar 

  • Plasse, T. F., Gorter, R. W., Krasnow, S. H., Lane, M., Shepard, K. V., and Wadleig, H. R. G.: Recent clinical experince with dronabinol.Pharmacol. Biochem. Behav. 40, 695–700 (1991).

    PubMed  Article  CAS  Google Scholar 

  • Sallan, S. E., Cronin, C., Zelen, M., and Zinberg, N. E.: Antiemetics in patients receiving chemotherapy for cancer: A randomized comparison of δ-9-tetrahydrocannabinol and prochlorperazine.N. Engl. J. Med. 302, 135–138 (1980).

    PubMed  CAS  Google Scholar 

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Baek, SH., Du Han, S., Yook, C.N. et al. Synthesis and antitumor activity of cannabigerol. Arch. Pharm. Res. 19, 228–230 (1996).

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Key words

  • Cannabigerol
  • Antitumor activity
  • Mouse skin melanoma cell