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A new sesquiterpene hydroperoxide from the aerial parts ofAster oharai

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Abstract

Phytochemical works on the aerial parts ofAster oharai (Compositae) led to the isolation of a new sesquiterpene hydroperoxide, 7α-hydroperoxy-3, 11-eudesmadiene (2) and seven known compounds, teucdiol B (1), α-spinasterol (3), oleanolic acid (4), α-spinasterol 3-O-β-D-glucopyranoside (5), methyl 3,5-di-O-caffeoyl quinate (6), 3,5-di-O-caffeoylquinic acid (7), 3,4-di-O-caffeoylquinic acid (8). The chemical structures of1–8 were established by chemical and spectroscopic methods. Compound2 showed cytotoxicity against cultured human tumor cell linesin vitro, SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), and HCT15 (colon) with ED50 values ranging from 3.86-17.21 ug/mL.

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Authors and Affiliations

  1. Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, 440-746, Suwon, Kyunggi-Do, Korea

    Sang Zin Choi, Sung Ok Lee, Sang Un Choi & Kang Ro Lee

  2. Korea Research Institute of Chemical Technology, 305-600, Taejeon, Korea

    Sang Un Choi

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  1. Sang Zin Choi
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  2. Sung Ok Lee
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  3. Sang Un Choi
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Correspondence to Kang Ro Lee.

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Choi, S.Z., Lee, S.O., Choi, S.U. et al. A new sesquiterpene hydroperoxide from the aerial parts ofAster oharai . Arch Pharm Res 26, 521–525 (2003). https://doi.org/10.1007/BF02976874

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  • DOI: https://doi.org/10.1007/BF02976874

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