Antioxidative constituents fromBuddleia officinalis

Abstract

Four flavonoids (1–4), a phenylethyl glycoside (5), and a phenylpropanoid glycoside (6) were isolated from the flowers ofBuddleia officinalis (Loganiaceae). Their structures were determined by chemical and spectral analysis. Among the isolated compounds, luteolin (1) and acteoside (6) exhibited the most potent antioxidative activity on the NBT superoxide scavenging assay. In addition, compounds1–6 revealed weak antifungal activity, and no hemolytic activity.

This is a preview of subscription content, access via your institution.

References

  1. Akdemir, Z. Ş., Tati, II., Saraccoğlu, L., ismailoğlu, U. B., Şahin-Erdemli, I., and Caliş, I., Polyphenolic compounds fromGeranium pratense and their free radical scavenging activities.Phytochemistry, 56, 189–193 (2001).

    PubMed  Article  CAS  Google Scholar 

  2. Blondle, S. E. and Houghten, R. A., Design of model amphipathic peptides having potent antimicrobial activities.Biochemistry, 31, 12688–12694 (1992).

    Article  Google Scholar 

  3. Ding, N., Yahara, S., and Nohara, T., Structure of mimengoside A, and B, new triterpenoid glycosides from Buddlejae Flos produced from China.Chem. Pharm. Bull., 40, 780–782 (1992).

    CAS  Google Scholar 

  4. Fan, W., Tezuka, Y., Komatsu, K., Namba, T., and Kadota, S., Prolyl endopeptidase inhibitors from the underground part ofRhodiola sacra S. H. Fu.Biol. Pharm. Bull., 22, 157–161 (1999).

    PubMed  CAS  Google Scholar 

  5. Fan, W., Tezuka, Y., Ni, K. M., and Kadota, S., Prolyl endopeptidase inhibitors from the underground part o.Rhodiola sachalinensis. Chem. Pharm. Bull., 49, 396–401 (2001).

    Article  CAS  Google Scholar 

  6. Kirby, A. J. and Schmidt, R. J., The antioxidant activity of Chinese herbs for eczema and of placebo herbs-I.J. Ethnopharmacol., 56, 103–108 (1997).

    PubMed  Article  CAS  Google Scholar 

  7. Houghton, P. J., Ethnopharmacology of someBuddleia species.J. Ethnopharmacol., 11, 293–308 (1984).

    PubMed  Article  CAS  Google Scholar 

  8. Houghton, P. J., Woldemariam, T. Z., Candau, M., Barnardo, A., Khen-Alafun, O., and Shangxiao, L., Buddlejone, a diterpene fromBuddleja albiflora.Phytochemistry, 42, 485–488 (1996)

    Article  CAS  Google Scholar 

  9. Jahn, B., Martin, E., Stueben, A., and Bhakdi, S., Susceptibility testing o.Candida albicans andAspergillus species by a simple microtiter menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay.J. Clin. Microbiol., 33, 661–667 (1995).

    PubMed  CAS  Google Scholar 

  10. Kim, H. J., Woo, E.-R., Shin, C.-G., Hwang, D. J., Park, H., and Lee, Y. S., HIV-1 integrase inhibitory phenylpropanoid glycosides fro.Clerodendron trichotomum.Arch. Pham. Res., 24, 286–291 (2001).

    CAS  Article  Google Scholar 

  11. Liao, Y.-H., Houghton, P. J., and Hoult, J. R. S., Novel and known constituents fromBuddleja species and their activity against leukocyte eicosanoid generation.J. Nat. Prod., 62, 1241–1245 (1999).

    PubMed  Article  CAS  Google Scholar 

  12. Matsuda H., Cai, H., Kubo M., Tosa H., and Inuma, M., Study on anti-cataract drugs from natural sources. II. Effects on Buddlejae Flos o.in vitro aldose reductase activity.Biol. Pharm. Bull., 18, 462–466 (1995).

    Google Scholar 

  13. Mensah, A. Y., Houghton, P. J., Bloomfield S., Vlietinck, A., and Berghe, D. V., Known and novel terpene fromBuddleja globosa displaying selective antifungal activity against dermatophytes.J. Nat. Prod., 63, 1210–1213 (2000).

    PubMed  Article  CAS  Google Scholar 

  14. Pardo, F., Perich, F., Villarroel, L., and Torres R., Isolation of verbascoside, an antimicrobial constituents o.Buddleja globosa leaves.J. Ethnopharmacol., 39, 221–222 (1993).

    Article  CAS  Google Scholar 

  15. Pietta, P-G., Flavonoids as antioxidants.J. Nat. Prod., 63, 1035–1042 (2000).

    PubMed  Article  CAS  Google Scholar 

  16. Zimin, L. and Zhongjian, J., Phenylpropanoid and iridoid glycosides fromPedicularis strata.Phytochemistry, 30, 1341–1344 (1991).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Piao Mei Shan or Kim Mi -Ran or Lee Dong Gun or Park Yoonkyung or Hahm Kyung -Soo or Moon Young -Hee or Woo Eun -Rhan.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mei Shan, P., Mi -Ran, K., Dong Gun, L. et al. Antioxidative constituents fromBuddleia officinalis . Arch Pharm Res 26, 453 (2003). https://doi.org/10.1007/BF02976861

Download citation

Key words

  • Buddleia officinalis
  • Antioxidant
  • NBT superoxide scavenging assay
  • Antifungal activity