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Inhibitory effect of Shimotsu-to, a traditional Chinese herbal prescription, on acute inflammation in rats and guinea pigs

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Abstract

We examined the effect of topical application of Shimotsu-to, a traditional Chinese herbal prescription, on carrageenin-induced edema in rats and ultraviolet radiation-induced erythema in guinea pigs. Shimotsu-to (5% in water) markedly suppressed an acute edema of rat hindpaw induced by 1% carrageenin, and was more effective than any other single crude drug componcent of Shimotsu-to, Topical treatment with this prescription also inhibited ultraviolet erythema on the back skin of guinea pigs (a human sunbrun model). These results suggest the therapeutic effect on acute inflammation by topical application of Shimotsu-to.

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Authors and Affiliations

  1. Research Laboratories, Hollywood Cosmetic Co., Ltd., 66-1, 3-chome, Chofu-shi, 182, Tokyo, Japan

    Katsuya Sakuma & Izumi Kaji

  2. Biochemical Pharmacology Group, Faculty of Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, 350-02, Saitama, Japan

    Masahiko Ogihara & Katsumi Yamamoto

Authors
  1. Katsuya Sakuma
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  2. Izumi Kaji
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  3. Masahiko Ogihara
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  4. Katsumi Yamamoto
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Sakuma, K., Kaji, I., Ogihara, M. et al. Inhibitory effect of Shimotsu-to, a traditional Chinese herbal prescription, on acute inflammation in rats and guinea pigs. Arch. Pharm. Res. 19, 122–125 (1996). https://doi.org/10.1007/BF02976846

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  • DOI: https://doi.org/10.1007/BF02976846

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