Eurycoma longifolia increases sexual motivation in sexually naive male rats

  • Hooi Hoon Ang
  • Meng Kwoon Sim
Notes

Abstract

The aim of this study is to provide evidence on the aphrodisiac property ofEurycoma longifolia Jack. An electric grid was used as an obstruction in the electrical copulation cage in order to determine how much an aversive stimulus the sexually naive male rat for both the treated withE. longifolia Jack and control groups were willing to overcome to reach the estrous receptive female in the goal cage. The intensity of the grid current was maintained at 0.12 mA and this was the intensity in which the male rats in the control group failed to crossover to reach the goal cage. Results showed thatE. longifolia Jack continued to enhance and also maintain a high level of both the total number of successful crossovers, mountings, intromissions and ejaculations during the 9–12 th week observation period. In conclusion, these results further enhanced and strenghtened the aphrodisiac property ofE. longifolia Jack.

Key words

Eurycoma longifolia Simaroubacease Sexual Motivation Successful crossovers Mountings Intromissions Ejaculations Aphrodisiac 

References Cited

  1. Ang, H. H., Chan, K. L. and Mak, J. W.,In vitro antimalarial activity of quassinoids fromEurycoma longifolia against Malaysian chloroquine-resistantPlasmodium falciparum isolates.Planta Med., 61, 177–178 (1995).PubMedCrossRefGoogle Scholar
  2. Ang, H. H., Chan, K. L. and Mak, J. W., Effect of 7-days daily replacement of culture medium containingEurycoma longifolia Jack constituents on the Malaysian Plasmodium falciparum isolates.J. Ethnopharmacol., 49, 171–175 (1995a).PubMedCrossRefGoogle Scholar
  3. Chan, K. L., O’Neill, M. J., Phillipson, J. D. and Warhurst, D. C., Plants as sources of antimalarial drugs. Part 3.Eurycoma longifolia JackPlanta Med., 52, 105–107 (1986)CrossRefGoogle Scholar
  4. Chan, K. L., Lee, S. P., Sam, T. W. and Han, B. H., A quassinoid glycoside from the roots ofEurycoma longifolia.Phytochem., 28, 2857–2859 (1989).CrossRefGoogle Scholar
  5. Chan, K. L., Lee, S. P. and Yuen, K. H., Antipyretic Activity of Quassinoids fromEurycoma longifolia Jack. Paper presented at the 11th Chemical Seminar on Natural Products, UNIMAS, Sarawak, Malaysia, proceedings pp. 197–204, 25–28 June, 1995.Google Scholar
  6. Diskow, C., Motion picture analysis of rat mating behavior.J. Comp. Physiol. Psychol., 88, 704–712 (1975).CrossRefGoogle Scholar
  7. Gimlette, J. D. and Thomson, J. W. (Eds.).A Dictionary of Malayan Medicine. Oxford University Press, Kuala Lumpur, pp. 183, 1977.Google Scholar
  8. Itokawa, H., Kishi, E., Morita, H. and Takeya, K., Cytotoxic Quassinoids and Tirucallane-Type Triterpenes from the Woods ofEurycoma longifolia.Chem. Pharm. Bull., 40, 1053–1055 (1992).Google Scholar
  9. Itokawa, H., Oin, X. R., Morita, H., Takeya, K. and Iitaka, Y., Novel Quassinoids fromEurycoma longifolia.Chem. Pharm. Bull., 41, 403–405 (1993).Google Scholar
  10. Kardono, L. B. S., Angerhofer, C. K., Tsauri, S., Padmawinata, K., Pezzuto, J. M. and Kinghorn, D., Cytotoxic and antimalarial constituents of the roots ofEurycoma longifolia.J. Nat. Prod., 54, 1360–1367 (1991).PubMedCrossRefGoogle Scholar
  11. Komisaruk, B. R. and Diakow, C., Lordosis reflex intensity in rats in relation to the estrous cycle, ovariectomy, estrogen, estrogen administration and mating behaviour.Endocrinol., 98, 548–557 (1973).CrossRefGoogle Scholar
  12. Kuehn, R. E. and Beach, F. A., Quantitative measurement of sexual receptivity in female rats.Behav., 21, 282–291 (1963).CrossRefGoogle Scholar
  13. Meyerson, B. J. and Lindstrom, L., In James, V. H. T. and Martini, L. (Eds.).Hormonal Steriods. Excerpta Medical International Congress, serial no. 219, 1971.Google Scholar
  14. Meyerson, B. J. and Lindstrom, L., Sexual motivation in the female rat.Act. Physiol. Scand. Suppl., 389, 1–80 (1973).Google Scholar
  15. Morita, H., Kishi, E., Takeya, K., Itokawa, H. and Iitaka, Y., New Quassinoids from the roots ofEurycoma longifolia.Chem. Lett., 5, 749–752 (1990).CrossRefGoogle Scholar
  16. Morita, H., Kishi, E., Takeya, K., Itokawa, H. and Iitaka, Y., Squalene derivatives fromEurycoma longifolia.Phytochem., 34, 765–771 (1993).CrossRefGoogle Scholar
  17. Sachs, B. D. and Barfield, R. J., Temporal patterning of sexual behaviour in the male rat.J. Comp. Physiol. Psychol., 73, 359–364 (1970).PubMedCrossRefGoogle Scholar
  18. Tada, H., Yasuda, F., Otani, K., Doteuchi, M., Ishihara, Y. and Shiro, M., New antiulcer quassinoids fromEurycoma longifolia.Eur. J. Med. Chem., 26, 345–349 (1991).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Hooi Hoon Ang
    • 1
  • Meng Kwoon Sim
    • 2
  1. 1.School of Pharmaceutical SciencesUniversity of Science MalaysiaPenangMalaysia
  2. 2.Department of Pharmacology, Faculty of MedicineNational University of SingaporeKent RidgeSingapore

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