Abstract
Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2’-hydroxy-3’-iodo-4’,6’-dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and8) showed moderate inhibitory activities of PGE2 production from LPS-induced RAW 264.7 cells.
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Dao, T.T., Oh, J.W., Chi, Y.S. et al. Synthesis and PGE2 inhibitory activity of vinylated and allylated chrysin analogues. Arch Pharm Res 26, 581–584 (2003). https://doi.org/10.1007/BF02976703
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DOI: https://doi.org/10.1007/BF02976703