Abstract
The methanolic extract of the twigs ofCeltis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation ofN-p-coumaroyl tyramine, as an inhibitor on AChE. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value oftrans-N-p-coumaroyl tyramine was 34.5 μg/mL (122 μM).
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Kim, D.K., Lee, K. Inhibitory effect ofTrans-N-p-coumaroyl tryamine from the twigs ofCeltis chinensis on the acetylcholinesterase. Arch Pharm Res 26, 735–738 (2003). https://doi.org/10.1007/BF02976684
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DOI: https://doi.org/10.1007/BF02976684